Results 121 to 130 of about 3,656,607 (353)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Liang you shipin ke-jiMycotoxins are toxic secondary metabolites produced by certain fungal species under specific conditions. Research has found that exposure to various fungal toxins can cause embryonic developmental toxicity, such as embryo arrest, abortion, and ...
HAN Xiao-min +8 more
doaj +1 more source
Highlights in the knowledge of brown spider toxins
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function.
Daniele Chaves-Moreira +5 more
doaj +1 more source
Special issue: Ribosome-inactivating proteins : commemorative issue in honor of Professor Fiorenzo Stirpe [PDF]
, 2017 The family of ribosome-inactivating proteins (RIPs) groups all enzymes (EC.3.2.2.22) with a so-called RIP domain which comprises N-glycosidase activity and enables these proteins to catalytically inactivate ribosomes.[...
Van Damme, Els
core +3 more sources
Marine Toxins Detection by Biosensors Based on Aptamers
Toxins, 2019 Marine toxins cause great harm to human health through seafood, therefore, it is urgent to exploit new marine toxins detection methods with the merits of high sensitivity and specificity, low detection limit, convenience, and high efficiency. Aptasensors
W. Ye +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Findings of the DRAFT 2004 Texas Water Quality Inventory and 303(d) List for the Austin Area [PDF]
, 2004 This 2004 summary of findings highlights the most common water quality impairments found in Waller Creek.The Texas Water Quality Inventory (305(b) report) is prepared by the Texas Commission on Environmental Quality (TCEQ) and submitted to the U.S ...
Gosselink, Leila
core +1 more source
Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome
Toxins, 2018 Cardiovascular disease (CVD) is highly prevalent in the setting of chronic kidney disease (CKD). Such coexistence of CVD and CKD—the so-called “cardiorenal or renocardiac syndrome”—contributes to exponentially increased risk of cardiovascular (CV ...
S. Lekawanvijit
semanticscholar +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes
Toxins, 2011 Venomous animals use their venoms as tools for defense or predation. These venoms are complex mixtures, mainly enriched of proteic toxins or peptides with several, and different, biological activities.
O. Chaim +11 more
semanticscholar +1 more source