Results 101 to 110 of about 2,296 (190)
Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma
Scientific Reports, 2017 Cancer cells can have different patterns of exon usage of individual genes when compared to normal tissue, suggesting that alternative splicing may play a role in shaping the tumor phenotype.
Sunniva Stordal Bjørklund +14 more
doaj +1 more source
F1000Research, 2018 Background: Androgen steroid hormones are key drivers of prostate cancer. Previous work has shown that androgens can drive the expression of alternative mRNA isoforms as well as transcriptional changes in prostate cancer cells.
Jennifer Munkley +9 more
doaj +1 more source
The Journal of Biochemistry, 2019 Abstract Nasopharyngeal carcinoma (NPC) is an important type of head and neck malignant cancer with geographical distribution. MicroRNA-449b-5p (miR-449b-5p) is related to the development of various cancers, while its function in NPC remains unknown.
Wei, Yin, Lei, Shi, Yanjiao, Mao
openaire +2 more sources
TPD52 is a prognostic biomarker and potential therapeutic target for ER+/PR+/HER2+ breast cancer
Chinese Clinical OncologyBreast cancer (BRCA) represents a significant health challenge for women globally, with refractory cases showing resistance to current therapeutic strategies. The discovery of novel molecular markers and therapeutic targets is critical for improving outcomes in these patients. The primary aim of this study is to elucidate the role of tumor protein D52 (
Xiaolin, Cheng +5 more
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United European Gastroenterology Journal, Volume 13, Issue 9, Page 1818-1839, November 2025.
wiley +1 more source
Role of tumor protein D52 in tumor occurrence and development, and its potential application value in tumor diagnosis and therapy [PDF]
, 2016 肿瘤蛋白D52(TPD52)在乳腺癌、前列腺癌、肺癌、卵巢癌和血液系统恶性病变等多种肿瘤中高表达,可参与肿瘤细胞增殖、侵袭、转移以及抑制DNA修复等生物学行为,并诱导机体产生对肿瘤的保护性免疫,是肿瘤诊断与分子靶向治疗中最有应用前景的候选蛋白之一。笔者对TPD52在肿瘤中发生发展的作用及其在肿瘤诊疗中潜在应用价值进行综述,旨在为TPD52进一步研究指明方向,更好实现其临床价值。Tumor protein D52(TPD52), which is involved in tumor cell ...
周思佳, 陈波, 骆明旭
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TPD52和TPD52L2在胃癌中异常表达的临床病理特征分析和相关基因共表达意义研究
Zhongguo shiyan zhenduanxue目的 应用生物信息学的方法探讨肿瘤蛋白D52(tumor protein D52,TPD52)和肿瘤蛋白D52样2(tumor protein D52-like 2,TPD52L2)在胃癌中异常表达的临床病理特征，并分析相关基因共表达的意义。方法 基于癌症基因组图谱(The Cancer Genome AHas, TCGA)获取数据，利用R语言软件包比较TPD52和TPD52L2在胃癌组织和癌旁组织中的差异表达与临床病理特征的相关性，并探索与免疫细胞浸润水平的情况，Kaplan ...
高夏青 +6 more
doaj
Comparative analysis of chromosome 8 copy number in paediatric solid tumours [PDF]
, 2017 Chromosomal imbalances are of major significance in cancer initiation and progression. Gains of chromosome 8 in human cancer have been described by a number of authors and are amongst the most common cytogenetic events that occur.
Martin La Rotta, Nancy Yamile Del Pilar
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