Results 91 to 100 of about 1,428 (171)
Inhibiting Tumor Protein D52 function for anti-cancer therapy application [PDF]
, 2013 Tumor protein D52 (TPD52) is amplified and/or overexpressed in many cancer types. Previously, TPD52 expression has been associated with ERBB2, suggesting these oncogenes may co-operate in cancer pathogenesis.
Roslan, Nuruliza
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Calcium‐dependent phosphorylation of TPD52 is mediated by a novel 46 kDa CAMKII isoform
The FASEB Journal, 2008 In the GI tract, tumor protein D52 is highly expressed in cells that undergo classical exocytosis and has been implicated as a regulator of this process. We have shown that the cholinergic agonist, carbachol, and the calcium ionophore, ionomycin, increase the phosphorylation of S136 in the D52 protein in gastric mucosal cells.
Catherine S. Chew +3 more
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Funktionelle Charakterisierung der Isoform 1 des TPD52-Proteins in einem Zellkulturmodell zum kastrationsresistenten Prostatakarzinom [PDF]
, 2017 Eine häufig therapiebedingte Spätkomplikation beim Prostatakarzinom ist die Ausprägung einer Kastrationsresistenz. Diese zeichnet sich durch eine von Androgenen unabhängige Progression aus.
Moritz, Tom
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Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma
Scientific Reports, 2017 Cancer cells can have different patterns of exon usage of individual genes when compared to normal tissue, suggesting that alternative splicing may play a role in shaping the tumor phenotype.
Sunniva Stordal Bjørklund +14 more
doaj +1 more source
F1000Research, 2018 Background: Androgen steroid hormones are key drivers of prostate cancer. Previous work has shown that androgens can drive the expression of alternative mRNA isoforms as well as transcriptional changes in prostate cancer cells.
Jennifer Munkley +9 more
doaj +1 more source
Functional significance of Tumor Protein D52 amplification and overexpression in cancer [PDF]
, 2018 Tumor Protein D52 (TPD52) is an oncogene whose overexpression has been demonstrated in tumours of diverse cellular origins and associated with poor prognosis.
Frost, Sarah
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The Journal of Biochemistry, 2019 Abstract Nasopharyngeal carcinoma (NPC) is an important type of head and neck malignant cancer with geographical distribution. MicroRNA-449b-5p (miR-449b-5p) is related to the development of various cancers, while its function in NPC remains unknown.
Wei, Yin, Lei, Shi, Yanjiao, Mao
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TPD52 is a prognostic biomarker and potential therapeutic target for ER+/PR+/HER2+ breast cancer
Chinese Clinical OncologyBreast cancer (BRCA) represents a significant health challenge for women globally, with refractory cases showing resistance to current therapeutic strategies. The discovery of novel molecular markers and therapeutic targets is critical for improving outcomes in these patients. The primary aim of this study is to elucidate the role of tumor protein D52 (
Xiaolin, Cheng +5 more
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Role of tumor protein D52 in tumor occurrence and development, and its potential application value in tumor diagnosis and therapy [PDF]
, 2016 肿瘤蛋白D52(TPD52)在乳腺癌、前列腺癌、肺癌、卵巢癌和血液系统恶性病变等多种肿瘤中高表达,可参与肿瘤细胞增殖、侵袭、转移以及抑制DNA修复等生物学行为,并诱导机体产生对肿瘤的保护性免疫,是肿瘤诊断与分子靶向治疗中最有应用前景的候选蛋白之一。笔者对TPD52在肿瘤中发生发展的作用及其在肿瘤诊疗中潜在应用价值进行综述,旨在为TPD52进一步研究指明方向,更好实现其临床价值。Tumor protein D52(TPD52), which is involved in tumor cell ...
骆明旭, 周思佳, 陈波
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United European Gastroenterology Journal, Volume 13, Issue 9, Page 1818-1839, November 2025.
wiley +1 more source