Results 71 to 80 of about 1,428 (171)

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source

Analysis of the CD8+ IL-10+ T cell response elicited by vaccination with the oncogenic tumor-self protein D52

Human Vaccines & Immunotherapeutics, 2020
Development of cancer vaccines targeting tumor self-antigens is complex and challenging due to the difficulty of overcoming immune tolerance to self-proteins.
C. Riccay Elizondo, Jennifer D. Bright, Jennifer A. Byrne, Robert K. Bright   +3 more
doaj   +1 more source

MicroRNA‑103a‑3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma

International Journal of Oncology, 2020
Salivary adenoid cystic carcinoma (SACC) exhibits slow continuous growth, frequent local recurrences and a high incidence of blood metastasis, with advanced lung metastasis frequently occurring and being among the primary causes of mortality. MicroRNAs (miR) serve a significant role in the initiation and development of cancer and may be tumour‑specific
Min Fu, Chuwen Chen, Lin‐Qian Yang, Wenwen Yang, Zhi‐Hao Du, Yin‐Ran Li, Shenglin Li, Xi‐Yuan Ge   +7 more
openaire   +3 more sources

Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes [PDF]

, 2017
The tumor protein D (TPD) family consists of four members, TPD52, TPD53, TPD54, and TPD55. The physiological roles of these genes in normal tissues, including epidermal and mesenchymal tissues, have rarely been reported.
Masakatsu Itose, Yoshiki Mukudai, Seiji Kondo, Tatsuo Shirota, Chihiro Ito, Toshikazu Shimane, Kosuke Kato, Hiromi Motohashi   +7 more
core   +1 more source

Brain metastasis in non‐small cell lung cancer: High‐risk factors and predictive models

VIEW, Volume 6, Issue 5, October 2025.
Artificial intelligence (AI) can integrate of data to predict brain metastases (BM) in non‐small cell lung cancer (NSCLC). AI algorithms are employed to analyze these multifaceted datasets, enabling the identification of complex patterns and correlations that may not be apparent through traditional analytical methods.
Chen Gong, Ben Zhao, Shuangshuang Mao, Qingxu Liu, Yuanyuan Zhao, Yiwen Liu, Yao Luo, Qianxia Li   +7 more
wiley   +1 more source

The imminent role of microRNAs in salivary adenoid cystic carcinoma

Translational Oncology, 2023
Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the correct molecular markers for ...
Pawan Kumar, Ram Kumar Kumawat, Vivek Uttam, Alisha Behera, Medha Rani, Neha Singh, Tushar Singh Barwal, Uttam Sharma, Aklank Jain   +8 more
doaj   +1 more source

SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish

Journal of Cellular Physiology, Volume 240, Issue 3, March 2025.
ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health and homeostasis of individuals. Dysregulation of HSPC function can lead to blood‐related diseases, including cancer. Despite its importance, our understanding of the genes and pathways underlying HSPC development and the ...
Chang‐Kyu Oh, Man S. Kim, Unbeom Shin, Ji Wan Kang, Yun Hak Kim, Hwa Soo Ko, Jae Sun Ra, Soyul Ahn, Eun Young Choi, Sanghyeon Yu, Uijeong Nam, Taesoo Choi, Kyungjae Myung, Yoonsung Lee   +13 more
wiley   +1 more source

BCL2, IRS1, AKT3, PTEN, and HIF1A expression levels in non‐small cell lung cancer patients

Malignancy Spectrum, Volume 2, Issue 1, Page 37-45, March 2025.
Restoration of miR‐15/16, miR‐126, and miR‐128 in NSCLC might be therapeutic candidates to control cell proliferation and apoptosis. Abstract Background Lung cancer is the leading cause of cancer‐related deaths worldwide. MicroRNAs (miRNAs) are small noncoding molecules that play critical roles in cell proliferation, apoptosis, invasion, and metastasis,
Mahdi Mohammadi, Kiana Taheri, Shamim Fooladgar, Saghar Omidvar Masoumi, Elham Tafsiri   +4 more
wiley   +1 more source

Patterns of TPD52 overexpression in multiple human solid tumor types analyzed by quantitative PCR

International Journal of Oncology, 2013
Tumor protein D52 (TPD52) is located at chromosome 8q21, a region that is frequently gained or amplified in multiple human cancer types. TPD52 has been suggested as a potential target for new anticancer therapies. In order to analyze TPD52 expression in the most prevalent human cancer types, we employed quantitative PCR to measure TPD52 mRNA levels in ...
Pierre, Tennstedt, Charlotte, Bölch, Gundula, Strobel, Sarah, Minner, Lia, Burkhardt, Tobias, Grob, Sawinee, Masser, Guido, Sauter, Thorsten, Schlomm, Ronald, Simon   +9 more
openaire   +3 more sources

ADAMTS5 Modulates Breast Cancer Development as a Diagnostic Biomarker and Potential Tumour Suppressor, Regulated by BAIAP2‐AS1, CRNDE and hsa‐miR‐135b‐3p: Integrated Systems Biology and Experimental Approach

IET Systems Biology, Volume 19, Issue 1, January/December 2025.
This study investigates the role of ADAMTS5 in breast cancer, revealing its low expression in tumour samples and its involvement in key pathways such as ECM‐receptor interactions and cell cycle regulation. A novel prognostic model was identified, highlighting interactions between ADAMTS5 and proteins such as COL10A1 and MMP1, as well as regulatory ...
Najmeh Tavousi, Qazal Taqizadeh, Elnaz Nasiriyan, Parastoo Tabaeian, Mohammad Rezaei, Mansoureh Azadeh   +5 more
wiley   +1 more source