TPD52L2 as a potential prognostic and immunotherapy biomarker in clear cell renal cell carcinoma
Frontiers in Oncology, 2023 BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics ...
Hongbo Wang +6 more
doaj +1 more source
MicroRNA‑103a‑3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma
International Journal of Oncology, 2020 Salivary adenoid cystic carcinoma (SACC) exhibits slow continuous growth, frequent local recurrences and a high incidence of blood metastasis, with advanced lung metastasis frequently occurring and being among the primary causes of mortality. MicroRNAs (miR) serve a significant role in the initiation and development of cancer and may be tumour‑specific
Min Fu +7 more
openaire +3 more sources
Brain metastasis in non‐small cell lung cancer: High‐risk factors and predictive models
VIEW, Volume 6, Issue 5, October 2025.Artificial intelligence (AI) can integrate of data to predict brain metastases (BM) in non‐small cell lung cancer (NSCLC). AI algorithms are employed to analyze these multifaceted datasets, enabling the identification of complex patterns and correlations that may not be apparent through traditional analytical methods.
Chen Gong +7 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2020 Development of cancer vaccines targeting tumor self-antigens is complex and challenging due to the difficulty of overcoming immune tolerance to self-proteins.
C. Riccay Elizondo +3 more
doaj +1 more source
Global gene expression in endometrium of high and low fertility heifers during the mid-luteal phase of the estrous cycle [PDF]
, 2014 peer-reviewedBackground In both beef and dairy cattle, the majority of early embryo loss occurs within the first 14 days following insemination.
Diskin, Michael G. +5 more
core +1 more source
Identification of genomic markers correlated with sensitivity in solid tumors to Dasatinib using sparse principal components [PDF]
, 2016 Background: Differential analysis techniques are commonly used to offer scientists a dimension reduction procedure and an interpretable gateway to variable selection, especially when confronting high-dimensional genomic data. Huang et al.
Ahmed Hossain +4 more
core +1 more source
Journal of Cellular Physiology, Volume 240, Issue 3, March 2025.ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health and homeostasis of individuals. Dysregulation of HSPC function can lead to blood‐related diseases, including cancer. Despite its importance, our understanding of the genes and pathways underlying HSPC development and the ...
Chang‐Kyu Oh +13 more
wiley +1 more source
MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors [PDF]
, 2020 Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have synergistic roles in cellular systems and their disruption may cause diseases including cancer.
Eischen, Christine M. +6 more
core +2 more sources
Biology of childhood germ cell tumours, focussing on the significance of microRNAs. [PDF]
, 2014 Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood.
Coleman, N, Murray, MJ, Nicholson, JC
core +2 more sources
Patterns of TPD52 overexpression in multiple human solid tumor types analyzed by quantitative PCR
International Journal of Oncology, 2013 Tumor protein D52 (TPD52) is located at chromosome 8q21, a region that is frequently gained or amplified in multiple human cancer types. TPD52 has been suggested as a potential target for new anticancer therapies. In order to analyze TPD52 expression in the most prevalent human cancer types, we employed quantitative PCR to measure TPD52 mRNA levels in ...
Pierre, Tennstedt +9 more
openaire +3 more sources