Results 61 to 70 of about 1,427 (143)

The imminent role of microRNAs in salivary adenoid cystic carcinoma

Translational Oncology, 2023
Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the correct molecular markers for ...
Pawan Kumar, Ram Kumar Kumawat, Vivek Uttam, Alisha Behera, Medha Rani, Neha Singh, Tushar Singh Barwal, Uttam Sharma, Aklank Jain   +8 more
doaj   +1 more source

SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish

Journal of Cellular Physiology, Volume 240, Issue 3, March 2025.
ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) play a pivotal role in blood cell production, maintaining the health and homeostasis of individuals. Dysregulation of HSPC function can lead to blood‐related diseases, including cancer. Despite its importance, our understanding of the genes and pathways underlying HSPC development and the ...
Chang‐Kyu Oh, Man S. Kim, Unbeom Shin, Ji Wan Kang, Yun Hak Kim, Hwa Soo Ko, Jae Sun Ra, Soyul Ahn, Eun Young Choi, Sanghyeon Yu, Uijeong Nam, Taesoo Choi, Kyungjae Myung, Yoonsung Lee   +13 more
wiley   +1 more source

Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes [PDF]

, 2017
The tumor protein D (TPD) family consists of four members, TPD52, TPD53, TPD54, and TPD55. The physiological roles of these genes in normal tissues, including epidermal and mesenchymal tissues, have rarely been reported.
Masakatsu Itose, Yoshiki Mukudai, Seiji Kondo, Tatsuo Shirota, Chihiro Ito, Toshikazu Shimane, Kosuke Kato, Hiromi Motohashi   +7 more
core   +1 more source

BCL2, IRS1, AKT3, PTEN, and HIF1A expression levels in non‐small cell lung cancer patients

Malignancy Spectrum, Volume 2, Issue 1, Page 37-45, March 2025.
Restoration of miR‐15/16, miR‐126, and miR‐128 in NSCLC might be therapeutic candidates to control cell proliferation and apoptosis. Abstract Background Lung cancer is the leading cause of cancer‐related deaths worldwide. MicroRNAs (miRNAs) are small noncoding molecules that play critical roles in cell proliferation, apoptosis, invasion, and metastasis,
Mahdi Mohammadi, Kiana Taheri, Shamim Fooladgar, Saghar Omidvar Masoumi, Elham Tafsiri   +4 more
wiley   +1 more source

ADAMTS5 Modulates Breast Cancer Development as a Diagnostic Biomarker and Potential Tumour Suppressor, Regulated by BAIAP2‐AS1, CRNDE and hsa‐miR‐135b‐3p: Integrated Systems Biology and Experimental Approach

IET Systems Biology, Volume 19, Issue 1, January/December 2025.
This study investigates the role of ADAMTS5 in breast cancer, revealing its low expression in tumour samples and its involvement in key pathways such as ECM‐receptor interactions and cell cycle regulation. A novel prognostic model was identified, highlighting interactions between ADAMTS5 and proteins such as COL10A1 and MMP1, as well as regulatory ...
Najmeh Tavousi, Qazal Taqizadeh, Elnaz Nasiriyan, Parastoo Tabaeian, Mohammad Rezaei, Mansoureh Azadeh   +5 more
wiley   +1 more source

Bayesian Optimization–Enhanced Machine Learning for Osteosarcoma Risk Stratification Based on Sphingolipid Metabolism

Human Mutation, Volume 2025, Issue 1, 2025.
Background: Heterogenized sphingolipid metabolism (SM) drives osteosarcoma tumorigenesis and its tumor‐promoting microenvironment. State‐of‐the‐art bioinformatic tools, such as machine learning, are essential for dissecting the prognostic value of SM by investigating its molecular and cellular mechanisms.
Yujian Zhong, Ruyuan He, Zewen Jiang, Queran Lin, Fei Peng, Wenyi Jin, Minghua Ren   +6 more
wiley   +1 more source

The role of TPD52 in the pancreatic β cell

, 2009
Tumour protein D52 is hypothesised to be involved in regulated secretion in the pancreatic acinar cell, indicated by rapid phosphorylation in response to secretagogue stimulation.
Manning, Yashka
core  

Circular RNAs in human diseases

MedComm, Volume 5, Issue 9, September 2024.
Circular RNAs (circRNAs) play significant roles in various human diseases, including respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal diseases, and cancer. This review highlights their biogenesis, pathogenic potential, and potential applications as diagnostic biomarkers and therapeutic targets. Abstract Circular RNAs (circRNAs)
Yuanyong Wang, Jin Zhang, Yuchen Yang, Zhuofeng Liu, Sijia Sun, Rui Li, Hui Zhu, Tian Li, Jin Zheng, Jie Li, Litian Ma   +10 more
wiley   +1 more source

Funktionelle Charakterisierung der Isoform 1 des TPD52-Proteins in einem Zellkulturmodell zum kastrationsresistenten Prostatakarzinom [PDF]

, 2017
Eine häufig therapiebedingte Spätkomplikation beim Prostatakarzinom ist die Ausprägung einer Kastrationsresistenz. Diese zeichnet sich durch eine von Androgenen unabhängige Progression aus.
Moritz, Tom
core   +1 more source

Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway

Cells, 2020
Breast cancer is the second greatest cause of cancer-related death in women. Resistance to endocrine treatments or chemotherapy is a limiting drawback.
Matteo Brindisi, Marco Fiorillo, Luca Frattaruolo, Federica Sotgia, Michael P. Lisanti, Anna Rita Cappello   +5 more
doaj   +1 more source