Results 161 to 170 of about 2,296 (190)

A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins

Biochemical and Biophysical Research Communications, 2006
Tumor protein D52-like proteins (TPD52) are small coiled-coil motif bearing proteins that were first identified in breast cancer. TPD52 and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human TPD52 members had been identified, named hD52 (TPD52), hD53 (TPD52L1), and hD54 (TPD52L2).
Qinhong, Cao, Jie, Chen, Li, Zhu, Yun, Liu, Zuomin, Zhou, Jiahao, Sha, Shui, Wang, Jianmin, Li   +7 more
openaire   +2 more sources

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening [PDF]

Molecular Biology Reports, 2014
Tumor protein D52 (TPD52) is overexpressed in different cancers, but its molecular functions are poorly defined. A large, low-stringency yeast two-hybrid screen using full-length TPD52 bait identified known partners (TPD52, TPD52L1, TPD52L2, MAL2) and four other preys that reproducibly bound TPD52 and TPD52L1 baits (PLP2, RAB5C, GOLGA5, YIF1A).
Brian J Smith, Yuyan Chen, Jennifer Anne Byrne   +2 more
exaly   +3 more sources

Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer

International Journal of Cancer, 2005
AbstractRecurrent chromosome 8q gain in ovarian carcinoma is likely to reflect the existence of multiple target loci, as the separate gain of chromosome bands 8q21 and 8q24 has been reported in independent studies. Since tumor protein D52 (TPD52) has been identified as a chromosome 8q21 amplification target in breast and prostate carcinoma, we compared
Jennifer A, Byrne, Rosemary L, Balleine, Marlena, Schoenberg Fejzo, Janelle, Mercieca, Yoke-Eng, Chiew, Yael, Livnat, Luke, St Heaps, Gregory B, Peters, Karen, Byth, Beth Y, Karlan, Dennis J, Slamon, Paul, Harnett, Anna, Defazio   +12 more
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TPD52 represents a survival factor inERBB2‐amplified breast cancer cells

Molecular Carcinogenesis, 2013
AbstractTPD52 and ERBB2 co‐expression has been persistently reported in human breast cancer and animal models of this disease, but the significance of this is unknown. We identified significant positive associations between relativeTPD52andERBB2transcript levels in human diagnostic breast cancer samples, and maximalTPD52expression in the hormone ...
Nuruliza, Roslan, Ivan, Bièche, Robert K, Bright, Rosette, Lidereau, Yuyan, Chen, Jennifer A, Byrne   +5 more
openaire   +2 more sources

Prognostic role of TPD52 in acute myeloid leukemia: A retrospective multicohort analysis

Journal of Cellular Biochemistry, 2018
AbstractGenerating accurate prognoses is extremely important for treating patients with cancer. Prognostic prediction based on messenger RNA (mRNA) expression has shown superior clinical value to other markers for some cancers but is not currently used for acute myeloid leukemia (AML).
Mihyang Ha, Myoung‐Eun Han, Ji‐Young Kim, Dae Cheon Jeong, Sae‐Ock Oh, Yun Hak Kim   +5 more
openaire   +2 more sources

Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells

Tumor Biology, 2016
The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration-resistant stage.
Moritz, Tom, Venz, Simone, Junker, Heike, Kreuz, Sarah, Walther, Reinhard, Zimmermann, Uwe   +5 more
exaly   +4 more sources

Heightened TPD52 linked to metabolic dysfunction and associated abnormalities in zebrafish

Archives of Biochemistry and Biophysics
The tumor protein D52 (TPD52) gene encodes a proto-oncogene protein associated with various medical conditions, including breast and prostate cancers. It plays a role in multiple biological pathways such as cell growth, differentiation, and apoptosis. The function of TPD52 in lipid droplet biosynthesis has been investigated in vitro.
Hsin-Hung Lai, Kuo-Shyang Jeng, Chung-Tsui Huang, An-Ju Chu, Guor Mour Her   +4 more
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microRNA-218 inhibits prostate cancer cell growth and promotes apoptosis by repressing TPD52 expression

Biochemical and Biophysical Research Communications, 2015
The tumor protein D52 (TPD52) is an oncogene overexpressed in prostate cancer (PC) due to gene amplification. Although the oncogenic effect of TPD52 is well recognized, how its expression is regulated is still not clear. This study tried to explore the regulative role of miR-218, a tumor suppressing miRNA on TPD52 expression and prostate cancer cell ...
Guangye, Han, Maochuan, Fan, Xinjun, Zhang   +2 more
exaly   +3 more sources

Functional Roles of Tumor Protein D52 (TPD52) in Breast Cancer

Current Cancer Therapy Reviews
: Breast cancer is an aggressive disease with a significant morbidity and death rate among women worldwide. Despite the progress of diagnostic and therapy options for breast cancer in recent years, the prognosis and survival rates of breast cancer patients remain unsatisfactory.
Mojtaba Zehtabi, Mohsen Maleknia, Amir Anbiyaiee, Razieh Mohammad Jafari, Farideh Moramezi, Maryam Farzaneh, Shirin Azizidoost   +6 more
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TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours

Molecular and Cellular Endocrinology, 2009
Several genomic regions are recurrently over- or underrepresented in testicular germ cell tumours (TGCTs), but only a fraction of their genes change their expression accordingly. Two publications to date have studied DNA copy numbers and associated gene expression changes on a genome-wide level to identify key players in TGCT tumorigenesis.
Sharmini, Alagaratnam, Jayne R, Hardy, Ragnhild A, Lothe, Rolf I, Skotheim, Jennifer A, Byrne   +4 more
openaire   +2 more sources