Results 151 to 160 of about 1,428 (171)

A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins

Biochemical and Biophysical Research Communications, 2006
Tumor protein D52-like proteins (TPD52) are small coiled-coil motif bearing proteins that were first identified in breast cancer. TPD52 and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human TPD52 members had been identified, named hD52 (TPD52), hD53 (TPD52L1), and hD54 (TPD52L2).
Qinhong, Cao, Jie, Chen, Li, Zhu, Yun, Liu, Zuomin, Zhou, Jiahao, Sha, Shui, Wang, Jianmin, Li   +7 more
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Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer

International Journal of Cancer, 2005
AbstractRecurrent chromosome 8q gain in ovarian carcinoma is likely to reflect the existence of multiple target loci, as the separate gain of chromosome bands 8q21 and 8q24 has been reported in independent studies. Since tumor protein D52 (TPD52) has been identified as a chromosome 8q21 amplification target in breast and prostate carcinoma, we compared
Jennifer A, Byrne, Rosemary L, Balleine, Marlena, Schoenberg Fejzo, Janelle, Mercieca, Yoke-Eng, Chiew, Yael, Livnat, Luke, St Heaps, Gregory B, Peters, Karen, Byth, Beth Y, Karlan, Dennis J, Slamon, Paul, Harnett, Anna, Defazio   +12 more
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TPD52 represents a survival factor inERBB2‐amplified breast cancer cells

Molecular Carcinogenesis, 2013
AbstractTPD52 and ERBB2 co‐expression has been persistently reported in human breast cancer and animal models of this disease, but the significance of this is unknown. We identified significant positive associations between relativeTPD52andERBB2transcript levels in human diagnostic breast cancer samples, and maximalTPD52expression in the hormone ...
Nuruliza, Roslan, Ivan, Bièche, Robert K, Bright, Rosette, Lidereau, Yuyan, Chen, Jennifer A, Byrne   +5 more
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Prognostic role of TPD52 in acute myeloid leukemia: A retrospective multicohort analysis

Journal of Cellular Biochemistry, 2018
AbstractGenerating accurate prognoses is extremely important for treating patients with cancer. Prognostic prediction based on messenger RNA (mRNA) expression has shown superior clinical value to other markers for some cancers but is not currently used for acute myeloid leukemia (AML).
Mihyang Ha, Myoung‐Eun Han, Ji‐Young Kim, Dae Cheon Jeong, Sae‐Ock Oh, Yun Hak Kim   +5 more
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Heightened TPD52 linked to metabolic dysfunction and associated abnormalities in zebrafish

Archives of Biochemistry and Biophysics
The tumor protein D52 (TPD52) gene encodes a proto-oncogene protein associated with various medical conditions, including breast and prostate cancers. It plays a role in multiple biological pathways such as cell growth, differentiation, and apoptosis. The function of TPD52 in lipid droplet biosynthesis has been investigated in vitro.
Hsin-Hung Lai, Kuo-Shyang Jeng, Chung-Tsui Huang, An-Ju Chu, Guor Mour Her   +4 more
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TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer

International Journal of Radiation Biology, 2007
Purpose: To evaluate a transcriptomic approach to identify healthy women at increased risk of breast cancer due to G2-radiosensitivity and look at transcripts that are differentially expressed between individuals.
Crispin J Miller, S D Bouffler, Anthony Howell   +2 more
exaly   +2 more sources

Functional Roles of Tumor Protein D52 (TPD52) in Breast Cancer

Current Cancer Therapy Reviews
: Breast cancer is an aggressive disease with a significant morbidity and death rate among women worldwide. Despite the progress of diagnostic and therapy options for breast cancer in recent years, the prognosis and survival rates of breast cancer patients remain unsatisfactory.
Mojtaba Zehtabi, Mohsen Maleknia, Amir Anbiyaiee, Razieh Mohammad Jafari, Farideh Moramezi, Maryam Farzaneh, Shirin Azizidoost   +6 more
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TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours

Molecular and Cellular Endocrinology, 2009
Several genomic regions are recurrently over- or underrepresented in testicular germ cell tumours (TGCTs), but only a fraction of their genes change their expression accordingly. Two publications to date have studied DNA copy numbers and associated gene expression changes on a genome-wide level to identify key players in TGCT tumorigenesis.
Sharmini, Alagaratnam, Jayne R, Hardy, Ragnhild A, Lothe, Rolf I, Skotheim, Jennifer A, Byrne   +4 more
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TPD52 Inhibits Aldosterone Synthesis Through Suppression of CAMKK2 Signaling

European Journal of Endocrinology
Abstract Background Aldosterone-producing adenomas (APA) are a major cause of primary aldosteronism. While gene mutations in APA trigger aldosterone overproduction via calcium signaling, their precise regulatory mechanisms remain unclear.
Ling Xie, Linqiang Ma, Bing Kang, Zhihao Chen, Shuangxin Qi, Manman Du, Jiayu Li, Junlong Li, Yifan He, Yong Xu, Wei Huang, Rufei Gao, Jinbo Hu, Shumin Yang, Qifu Li, Chuan Peng   +15 more
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TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis

Current Molecular Medicine
Background: Some tumors have a poor prognosis regarding TPD52 (tumor protein D52). This study aims to explore TPD52's role in the cancer process from a pan-cancer perspective. Methods: A pan-cancer analysis was conducted to investigate how TPD52 may be involved in cancer as well as its association with prognosis.
Lu Miao, Li Jing, Buze Chen, Tian Zeng, Youguo Chen   +4 more
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