Using interspecies biological networks to guide drug therapy [PDF]
, 2017 The use of drug combinations (DCs) in cancer therapy can prevent the development of drug resistance and decrease the severity and number of side effects. Synthetic lethality (SL), a genetic interaction wherein two nonessential genes cause cell death when
Jacunski, Alexandra
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Constructing gene expression based prognostic models to predict recurrence and lymph node metastasis in colon cancer [PDF]
, 2008 The main goal of this study is to identify molecular signatures to predict lymph node metastases and recurrence in colon cancer patients. Recent advances in microarray technology facilitated building of accurate molecular classifiers, and in depth ...
Mettu, Ramakanth Reddy
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Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues [PDF]
, 2010 Background Cell lines are commonly used in various kinds of biomedical research in the world. However, it remains uncertain whether genomic alterations existing in primary tumor tissues are represented in cell lines and whether cell lines carry cell line-
A Bergamaschi +51 more
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Defining the molecular pathology of pancreatic body and tail adenocarcinom [PDF]
, 2018 Background: Pancreatic ductal adenocarcinoma (PDAC) remains a dismal disease, with very little improvement in survival over the past 50 years. Recent large-scale genomic studies have improved understanding of the genomic and transcriptomic landscape of
Australian Pancreatic Cancer Genome Initiative, +7 more
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Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach [PDF]
, 2014 Data on neurobiological mechanisms underlying mood disorders are elusive; the aetiology of such states is multifactorial, including genetic predisposition and environmental factors. Diagnosis is currently being made only on an interview-based methodology.
VENTRONI, TIZIANA
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Differential splicing using whole-transcript microarrays [PDF]
, 2009 Background The latest generation of Affymetrix microarrays are designed to interrogate expression over the entire length of every locus, thus giving the opportunity to study alternative splicing genome-wide.
A Bemmo +30 more
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Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of ...
Alejandra Perez +6 more
core
TPD52和TPD52L2在胃癌中异常表达的临床病理特征分析和相关基因共表达意义研究
Zhongguo shiyan zhenduanxue目的 应用生物信息学的方法探讨肿瘤蛋白D52(tumor protein D52,TPD52)和肿瘤蛋白D52样2(tumor protein D52-like 2,TPD52L2)在胃癌中异常表达的临床病理特征，并分析相关基因共表达的意义。方法 基于癌症基因组图谱(The Cancer Genome AHas, TCGA)获取数据，利用R语言软件包比较TPD52和TPD52L2在胃癌组织和癌旁组织中的差异表达与临床病理特征的相关性，并探索与免疫细胞浸润水平的情况，Kaplan ...
高夏青 +6 more
doaj
Substrate Identification of an Oncogenic Kinase: Elucidating the Pathogenesis of a Rare Liver Cancer [PDF]
, 2019 Fibrolamellar Hepatocellular Carcinoma (FLC) is a rare liver cancer with limited treatment options. This cancer primarily affects adolescents and young adults. Our lab has identified a new fusion gene in this cancer called DNAJB1-PRKACA that results from
Jarmel, Melissa
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TPD52 (tumor protein D52) [PDF]
, 2011 Review on TPD52 (tumor protein D52), with data on DNA, on the protein encoded, and where the gene is ...
Byrne, J, Della-Franca, A
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