Results 171 to 180 of about 8,275 (209)

Duplex pyrosequencing of the TPMT⁎3C and TPMT⁎6 alleles in Korean and Vietnamese populations

Clinica Chimica Acta, 2008
Thiopurine S-methyltransferase (TPMT) genetic polymorphisms have been studied intensively in relation to thiopurine toxicity. In the present study, an improved pyrosequencing method was developed for TPMT genotyping and used to investigate the genotype frequency in Korean and Vietnamese populations.Four-hundred Korean and 159 Vietnamese subjects were ...
Sang Seop, Lee, Woo-Young, Kim, Yin-Jin, Jang, Jae-Gook, Shin   +3 more
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TPMT Polymorphism: When Shield Becomes Weakness

Interdisciplinary Sciences: Computational Life Sciences, 2015
Thiopurine methyltransferase (TPMT) is a cytoplasmic transmethylase present in both prokaryotes and eukaryotes. In humans, it shows its presence in almost all of the tissues, predominantly in liver and kidney. TPMT is one of the important metabolic enzymes of phase II metabolic pathway and catalyzes methylation of thiopurine drugs such as azathioprine,
Pramod, Katara, Himani, Kuntal
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Functional Analysis of the Role of theTPMTGene Promoter VNTR Polymorphism inTPMTGene Transcription

Pharmacogenomics, 2010
Thiopurine S-methyltransferase (TPMT) activity is polymorphic, and a trimodal distribution has been demonstrated in Caucasians (low, intermediate and high methylator groups). The TPMT gene promoter contains a variable number of three GC-rich tandem repeats, namely A, B and C, ranging from three to nine in length in a A(n)B(m)C architecture.Here, we ...
Zukić, Branka, Radmilović Milena, Stojiljković, Maja, Tošić, Nataša, Pourfarzad, Farzin, Dokmanović, Lidija, Janić, Dragana, Čolović, Nataša, Philipsen, Sjaak, Patrinos, George P., Pavlović, Sonja   +10 more
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Whose TPMT activity is it anyway?

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2004
Determination of thiopurine S-methyltransferase (TPMT) activity prior to starting azathioprine therapy is used to identify individuals with low or deficient TPMT activities who are at risk of severe complications and even death This case describes a patient treated with azathioprine without prior knowledge of TPMT status. Pancytopaenia developed over
Loretta, Ford, Catherine, Prout, Dairena, Gaffney, Jonathan, Berg   +3 more
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Development of a rapid clinical TPMT genotyping assay

Clinical Biochemistry, 2014
Thiopurine compounds are commonly used in the treatment of childhood acute lymphoblastic leukemia, and as immunosuppressants following organ transplantation or for treatment of various autoimmune disorders. Thiopurine S-methyltransferase (TPMT) is required for detoxification, through S-methylation, of 6-thioguanine nucleotides (TGNs), a byproduct of ...
Paul R. Burchard, Ahmad N. Abou Tayoun, Joel A. Lefferts, Lionel D. Lewis, Gregory J. Tsongalis, Mark A. Cervinski   +5 more
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TPMT testing before azathioprine therapy?

Drug and Therapeutics Bulletin, 2009
Azathioprine has been in use for decades as an immunosuppressant treatment for various autoimmune diseases. It is a prodrug of mercaptopurine, a substance that is subsequently metabolised by several alternative pathways, one of which involves the enzyme thiopurine methyltransferase (TPMT).
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6-Mercaptopurine influences TPMT gene Transcription in a TPMT Gene Promoter Variable Number of Tandem Repeats-Dependent Manner

Pharmacogenomics, 2012
TPMT activity is characterized by a trimodal distribution, namely low, intermediate and high methylator. TPMT gene promoter contains a variable number of GC-rich tandem repeats (VNTRs), namely A, B and C, ranging from three to nine repeats in length in an A(n)B(m)C architecture.
Kotur, Nikola, Stanković, Biljana, Kassela, Katerina, Georgitsi, Marianthi, Vicha, Anna, Leontari, Iliana, Dokmanović, Lidija, Janić, Dragana, Krstovski, Nada, Klaassen, Kristel, Radmilović, Milena, Stojiljković, Maja, Nikčević, Gordana, Simeonidis, Argiris, Sivolapenko, Gregory, Pavlović, Sonja, Patrinos, George P., Zukić, Branka   +17 more
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Thiopurinemethyltransferase (TPMT) genotype and TPMT activity in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: relation to azathioprine maintenance treatment and adverse effects

Annals of the Rheumatic Diseases, 2009
Azathioprine is used in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to maintain remission. Azathioprine is inactivated and converted into hepatotoxic metabolites by the enzyme thiopurine methyltransferase (TPMT). Polymorphisms in the gene encoding TPMT lead to differences in activity of the enzyme.
Stassen, P. M., Derks, R. P. H., Kallenberg, C. G. M., Stegeman, C. A.   +3 more
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TPMT Gene Polymorphisms in Croatian Population

European journal of human genetics, 2006
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of azathioprine (AZA), 6-mercaptopurine (6-MP) and thioguanine, medications widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease and solid organ transplantat rejection. Low TPMT activity plays a significant role in the occurence of life-
Kapitanović, Sanja, Jokić, Mladen, Jurišić, Giorgia   +2 more
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TPMT and NUDT15 genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience

Pharmacogenomics
To share the experience of a US national reference laboratory, offering genotyping for TPMT and NUDT15, TPMT enzyme phenotyping and detection of thiopurine metabolites.Retrospective review of archived datasets related to thiopurines drug therapy including patients' data that underwent TPMT and NUDT15 genotyping, and smaller data sets where genotyping ...
Sherin, Shaaban, Brandon S, Walker, Yuan, Ji, Kamisha, Johnson-Davis   +3 more
openaire   +2 more sources