Results 111 to 120 of about 4,795 (186)

The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

Cell Reports, 2019
Summary: Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated (ATM) and ATM and Rad3-related (ATR) dependent DNA damage checkpoint responses.
Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang   +5 more
doaj   +1 more source

Effects of TPP1 overexpression on the radiosensitivity and cell cycle in HCT116 cells.

, 2013
(A)Verification of TPP1 overexpression by western blotting. (B) HCT116-Mock and-TPP1 cells were irradiated with X-rays and then cell survival was determined using clonogenic assay.
Wenbo Wang (300277), Haijun Yu (417023), Yunfeng Zhou (417027), Zheng Li (26302), Liu Hu (417021), Xiaoxi Yang (486981), Hui Yang (91136), Han Lei (417024), ZhengKai Liao (5656954), Lei Yang (102719), Fuxiang Zhou (417026), Juan Zhong (486982), Conghua Xie (282964)   +12 more
core   +1 more source

Telomere Protection by TPP1 Is Mediated by POT1a and POT1b

, 2009
Mammalian telomeres are protected by the shelterin complex, which contains single-stranded telomeric DNA binding proteins (POT1a and POT1b in rodents, POT1 in other mammals).
Catherine E. Keegan, Gail A. Osawa, Tatsuya Kibe, Titia De Lange   +3 more
core  

Abstract 5745: Study on telomere shelterin component TPP1 in esophageal squamous cell carcinoma

, 2017
Esophageal cancer (EC) is one of the most aggressive cancer and ranks the sixth leading cause of cancer-related mortality worldwide, approximately 70% of global esophageal carcinoma cases occur in China and esophageal squamous cell carcinoma (ESCC) is ...
Jiajing Cai, Ru Sun, Lei Xu, Qiang Ma, Guangcheng Huang, Xiaolan Guo, Jiang Zou, Lihua Yao, Mayong Fu   +8 more
core   +1 more source

Mutation update: Review of TPP1 gene variants associated with neuronal ceroid lipofuscinosis CLN2 disease [PDF]

, 2019
Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an autosomal recessive condition caused by variants in the TPP1 gene, leading to deficient activity of the lysosomal enzyme tripeptidyl peptidase I (TPP1). We update on the spectrum of TPP1 variants
Miller, N, Bailey, M, Aristorena, M, Gardner, E, Mole, SE, Schulz, A   +5 more
core   +1 more source

Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis

, 2015
The CLN2 form of neuronal ceroid lipofuscinosis, a type of Batten disease, is a lysosomal storage disorder caused by a deficiency of the enzyme tripeptidyl peptidase-1 (TPP1).
Kennedy, Derek, Butt, Mark T., Cooper, Jonathan D., Adams, Eric L., Wong, Andrew M S, Johnson, Gayle C., Henshaw, Joshua, Katz, Martin L., Keve, Steve, O'Neill, Charles A., Doeleman, Thom, Cahayag, Rhea, Reed, Randall P., Musson, Donald G., Sri, Sarmi, Coates, Joan R., Tsuruda, Laurie S., Vuillemenot, Brian R.   +17 more
core   +1 more source

Combatting cellular immortality in cancers by targeting the shelterin protein complex

Biology Direct
Shelterin proteins (TERF1, TERF2, TPP1, TINF2, POT1) protect telomeres, prevent unwarranted repair activation, and regulate telomerase activity. Alterations in these proteins can lead to cancer progression.
Sohini Chakraborty, Satarupa Banerjee
doaj   +1 more source

The neuronal ceroid lipofuscinosis type 2 – associated variants: An analysis of alterations in the TPP1 gene and genotype–phenotype correlation in Ukraine

JIMD Reports
The neuronal ceroid lipofuscinosis type 2 (CLN2) is a heterogeneous group of neurodegenerative lysosomal storage disorders caused by autosomal recessive inheritance of two pathogenic variants in trans in the TPP1 gene.
Nataliia Olkhovych, Nataliia Pichkur, Nataliia Mytsyk, Rodolfo Tonin, Svitlana Kormoz, Iryna Hregul, Nataliia Samonenko, Tetiana Shklyarskaya, Volodymyr Olkhovych, Olexandr Buryak, Amelia Morrone, Nataliia Gorovenko   +11 more
doaj   +1 more source

Single-Cell and Multi-Omics-Based Characterization of Gastric Cancer Identifies TPP1 as a Potential Target for Gastric Cancer Progression and Treatment. [PDF]

Oncol Res
Zhao Y, Ma J, Huang R, Pan S.
europepmc   +1 more source

PPARα and RXRα in the regulation of neuronal ceroid lipofuscinosis genes: implications for Batten disease therapy. [PDF]

NeuroImmune Pharm Ther
Chandra S, Pahan K.
europepmc   +1 more source