Results 101 to 110 of about 4,795 (186)

Linker sequences affect lysosomal targeting of TPP1 fusion proteins.

, 2014
A) U2OS cells were transiently transfected with indicated fusion constructs. Linker sequences are as described in Fig. 3 legend. Endocytosed Alexa488-NPC2 is used as a lysosomal standard. The scale bar (white) in the bottom right corner represents 20 µm.
Ling Huang (51752), David E. Sleat (152563), Douglas Pike (526096), Vikas Nanda (172915), Peter Lobel (152571)   +4 more
core   +1 more source

Expression of TPP1 fusion proteins.

, 2014
CHO cells were transiently transfected as indicated. Media was collected at 24) TPP1 and β-galactosidase activity measured in media and cell lysates. Data represents total activity in media (24 and 48-hour collection points) and cells.
Ling Huang (51752), David E. Sleat (152563), Douglas Pike (526096), Vikas Nanda (172915), Peter Lobel (152571)   +4 more
core   +1 more source

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease

Molecular Therapy: Methods & Clinical Development, 2017
Late infantile neuronal ceroid lipofuscinosis (LINCL) is a fatal inherited neurodegenerative disease caused by loss of lysosomal protease tripeptidyl peptidase 1 (TPP1).
Jennifer A. Wiseman, Yu Meng, Yuliya Nemtsova, Paul G. Matteson, James H. Millonig, Dirk F. Moore, David E. Sleat, Peter Lobel   +7 more
doaj   +1 more source

Intravitreal implantation of TPP1-transduced stem cells delays retinal degeneration in canine CLN2 neuronal ceroid lipofuscinosis [PDF]

, 2016
The CLN2 form of neuronal ceroid lipofuscinosis is a neurodegenerative disease that results from mutations in the TPP1 gene. Affected children exhibit progressive declines in most neurological functions including vision.
Williamson, Baye G., Vansteenkiste, Daniella P., Whiting, Rebecca E.H., Coates, Joan R., Jensen, Cheryl A., Tracy, Christopher J., Katz, Martin L., Gillespie, Lauren E., Bryan, Jeffrey N., Pearce, Jacqueline W., Castaner, Leilani J.   +10 more
core   +1 more source

A mechanistic study of POT1-TPP1 mediated human telomerase processivity

, 2009
Telomerase contributes to telomere replication by synthesizing repeats of DNA, and two telomeric DNA-binding proteins, POT1 and TPP1, synergistically increase its repeat addition processivity.
Latrick, Chrysa Marie
core  

TPP1 production, radiosensitivity (SF2) and telomere length (TRF) in human colorectal cancer cell lines.

, 2013
(A) TPP1 production was detected by western blotting.. (B) Telomere length was examined by Southern blot analysis. (C) Relative TPP1 production, radiosensitivity (SF2) and telomere length (TRF) in human colorectal cancer cell lines.
Wenbo Wang (300277), Haijun Yu (417023), Yunfeng Zhou (417027), Zheng Li (26302), Liu Hu (417021), Xiaoxi Yang (486981), Hui Yang (91136), Han Lei (417024), ZhengKai Liao (5656954), Lei Yang (102719), Fuxiang Zhou (417026), Juan Zhong (486982), Conghua Xie (282964)   +12 more
core   +1 more source

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease [PDF]

, 2019
Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported.
Haney, M.J., Batrakova, E.V., Harrison, E.B., Klyachko, N.L., Kabanov, A.V., Zhao, Y.   +5 more
core   +1 more source

Correction: Zebrafish as a Model System to Study the Physiological Function of Telomeric Protein TPP1

PLoS ONE, 2011
The 2nd affiliation for the 4th author was not indicated. Zhou Songyang is affiliated with both 1 State Key laboratory for Biocontrol, Sun Yat-Sen University, Guangzhou, People's Republic of China, and 2 Verna and Marrs McLean Department of Biochemistry and Molecular biology, Baylor College of Medicine, Houston, Texas, United States of America.
Yiying Xie, Dong Yang, Quanyuan He, Zhou Songyang   +3 more
openaire   +3 more sources

Immunostaining for TPP1.

, 2012
Tpp1(−/−) mice were administered unmodified enzyme or vehicle alone via tail vein injection and tissues collected after 24 hours. Tissue processing and immunostaining was conducted as described previously [33].
Istvan Sohar (152558), Lingling Wang (66269), David E. Sleat (152563), Yu Meng (152553), Peter Lobel (152571)   +4 more
core   +1 more source

Club cell‐specific telomere protection protein 1 (TPP1) protects against tobacco smoke‐induced lung inflammation, xenobiotic metabolic dysregulation, and injurious responses

FASEB BioAdvances
Inhaling xenobiotics, such as tobacco smoke is a major risk factor for pulmonary diseases, e.g., COPD/emphysema, interstitial lung disease, and pre‐invasive diseases.
Thivanka Muthumalage, Chiara Goracci, Irfan Rahman   +2 more
doaj   +1 more source