Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition [PDF]
Cells, 2021 Protecting telomere from the DNA damage response is essential to avoid the entry into cellular senescence and organismal aging. The progressive telomere DNA shortening in dividing somatic cells, programmed during development, leads to critically short ...
Claire Ghilain +2 more
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Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer [PDF]
Biochemistry and Biophysics Reports, 2021 Telomere encompasses a (TTAGGG)n tandem repeats, and its dysfunction has emerged as the epicenter of driving carcinogenesis by promoting genetic instability.
Vikas Kumar Bhari +3 more
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Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations [PDF]
Cells, 2020 Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases.
Mohd. Amir +8 more
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Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex. [PDF]
PLoS Genetics, 2022 The conserved shelterin complex caps chromosome ends to protect telomeres and regulate telomere replication. In fission yeast Schizosaccharomyces pombe, shelterin consists of telomeric single- and double-stranded DNA-binding modules Pot1-Tpz1 and Taz1 ...
Hong Sun +9 more
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High‐fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue [PDF]
Physiological Reports, 2020 Obesity and aging are linked to inflammation and increased risk of chronic disease. Telomeres are the endcaps of chromosomes that are regulated by telomerase, the enzyme that elongates telomeres, as well as a protein complex known as shelterin.
Samuel I. Bloom +3 more
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Shelterin Complex at Telomeres: Implications in Ageing [PDF]
Clinical Interventions in Aging, 2020 Seyed Mostafa Mir,1– 3 Sadra Samavarchi Tehrani,4,5 Golnaz Goodarzi,4,5 Zahra Jamalpoor,1 Jahanbakhsh Asadi,6 Nafiseh Khelghati,7 Durdi Qujeq,2,3 Mahmood Maniati8 1Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran; 2Student ...
Mir SM +7 more
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Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites [PDF]
Epigenetics & Chromatin, 2017 Background Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells and has been associated with various diseases, including many cancers.
Aleksandar Ilic +7 more
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres [PDF]
Cell ReportsSummary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. Shelterin is composed of six proteins (TRF1, TRF2, TIN2, TPP1, POT1, and RAP1) that can assemble into various subcomplexes in ...
Tomáš Janovič +3 more
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Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications. [PDF]
Wiley Interdiscip Rev RNASchematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Felicitus S +5 more
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Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening [PDF]
Scientific ReportsTRF1 is a subunit of the shelterin complex that binds to and protects the linear ends of chromosomes known as telomeres. Both genetic deletion and chemical inhibition of TRF1 have been shown to block the growth of lung carcinoma, glioblastoma, and renal ...
Giacomo Casale +8 more
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