Results 21 to 30 of about 4,729 (146)

Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells. [PDF]

Nucleic Acids Res, 2021
Abstract Telomere maintenance is essential to preserve genomic stability and involves telomere-specific proteins, DNA replication and repair proteins. Lamins are key components of the nuclear envelope and play numerous roles, including maintenance of the nuclear integrity, regulation of transcription, and DNA replication. Elevated levels
Pennarun G, Picotto J, Etourneaud L, Redavid AR, Certain A, Gauthier LR, Fontanilla-Ramirez P, Busso D, Chabance-Okumura C, Thézé B, Boussin FD, Bertrand P.   +11 more
europepmc   +4 more sources

Prognostic significance of dysregulation of shelterin complex and its correlation with telomere length and cytogenetics in multiple myeloma. [PDF]

J Genet Eng Biotechnol, 2023
MM (multiple myeloma) is a bone marrow disease with the accumulation of malignant plasma cells characterized by the neoplastic transformation of differentiated B cells. The onset and progression of cancer are greatly influenced by telomere dysfunction. We aimed to study the biomarker potential and prognostic significance of shelterin complex and hTERT.
Kalal AA, Shetty RA, Manjappa AB, Kulkarni NV, Shetty P.   +4 more
europepmc   +4 more sources

Heregulin, a new interactor of the telosome/shelterin complex in human telomeres. [PDF]

Oncotarget, 2015
Telomere length, shape and function depend on a complex of six core telomere-associated proteins referred to as the telosome or shelterin complex. We here demonstrate that the isoform β2 of the heregulin family of growth factors (HRGβ2) is a novel interactor of the telosome/shelterin complex in human telomeres.
Menendez JA, Benboudjema L, Vellon L, Rubio MA, Espinoza I, Campisi J, Lupu R.   +6 more
europepmc   +5 more sources

Germline mutations in shelterin complex genes are associated with familial glioma. [PDF]

J Natl Cancer Inst, 2015
Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing of 90 individuals from 55 families, we identified two families with mutations in POT1 (p.G95C, p.E450X), a member of the telomere shelterin complex ...
Bainbridge MN, Armstrong GN, Gramatges MM, Bertuch AA, Jhangiani SN, Doddapaneni H, Lewis L, Tombrello J, Tsavachidis S, Liu Y, Jalali A, Plon SE, Lau CC, Parsons DW, Claus EB, Barnholtz-Sloan J, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Walsh KM, Davis FG, Lai R, Shete S, Aldape K, Amos CI, Thompson PA, Muzny DM, Gibbs RA, Melin BS, Bondy ML, Gliogene Consortium.   +39 more
europepmc   +4 more sources

The Impact of Dietary Melatonin on Heart and Lung Telomere Length and Shelterin Protein Gene Expression of Pulmonary Hypertensive Broiler Chickens [PDF]

Veterinary Medicine and Science
Objectives Pulmonary hypertension syndrome (PHS) is a common metabolic disease in broiler chickens linked to oxidative stress. This study explored the potential of melatonin, an antioxidant, to improve PHS response and telomere structure in chickens with
Peyman Gheytaspour, Shahab Bahadoran, Hossein Hassanpour   +2 more
doaj   +2 more sources

Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres

Life Science Alliance, 2021
This study unveils a role of Ccq1–Raf2 interaction in CLRC recruitment to establish heterochromatin at telomeres, providing a positive feedback mechanism between shelterin and CLRC for subtelomeric heterochromatin assembly.
Shaohua Shi, Yuanze Zhou, Yanjia Lu, Hong Sun, Jing Xue, Zhenfang Wu, Ming Lei   +6 more
doaj   +1 more source

Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation. [PDF]

Cell Discov, 2019
AbstractTelomere maintenance is critical for chromosome stability. Here we report that periodic tryptophan protein 1 (PWP1) is involved in regulating telomere length homeostasis. Pwp1 appears to be essential for mouse development and embryonic stem cell (ESC) survival, as homozygous Pwp1-knockout mice and ESCs have never been obtained.
Yu Y, Jia W, Lyu Y, Su D, Bai M, Shen J, Qiao J, Han T, Liu W, Chen J, Chen W, Ye D, Guo X, Zhu S, Xi J, Zhu R, Wan X, Gao S, Zhu J, Kang J.   +19 more
europepmc   +4 more sources

Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension. [PDF]

PLoS Genetics, 2013
Studies in fission yeast have previously identified evolutionarily conserved shelterin and Stn1-Ten1 complexes, and established Rad3(ATR)/Tel1(ATM)-dependent phosphorylation of the shelterin subunit Ccq1 at Thr93 as the critical post-translational ...
Ya-Ting Chang, Bettina A Moser, Toru M Nakamura   +2 more
doaj   +1 more source

RE: Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma. [PDF]

J Natl Cancer Inst, 2015
The title of the paper by Bainbridge et al. (1) is an assertion that is not supported by the evidence presented. A genetic mutation is (positively) associated with a disease when a carrier of the mutation is more likely to contract the disease than a noncarrier or (equivalently) when a sufferer of the disease is more likely to carry the mutation than a
Cooke JG.
europepmc   +4 more sources

The telosome/shelterin complex and its functions [PDF]

Genome Biology, 2008
The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its ...
Xin, Huawei, Liu, Dan, Songyang, Zhou
openaire   +2 more sources