Results 41 to 50 of about 4,729 (146)
Cell Reports, 2015 Shelterin, a six-member complex, protects telomeres from nucleolytic attack and regulates their elongation by telomerase. Here, we have developed a strategy, called MICro-MS (Mapping Interfaces via Crosslinking-Mass Spectrometry), that combines ...
Jinqiang Liu +8 more
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POT1-TPP1 telomere length regulation and disease
Computational and Structural Biotechnology Journal, 2020 Telomeres are DNA repeats at the ends of linear chromosomes and are replicated by telomerase, a ribonucleoprotein reverse transcriptase. Telomere length regulation and chromosome end capping are essential for genome stability and are mediated primarily ...
Tomas Aramburu +2 more
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Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
Nature Reviews Molecular Cell Biology, 2021 The regulation of telomere length in mammals is crucial for chromosome end-capping and thus for maintaining genome stability and cellular lifespan. This process requires coordination between telomeric protein complexes and the ribonucleoprotein telomerase, which extends the telomeric DNA.
Ci Ji Lim, Thomas R. Cech
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AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. [PDF]
PLoS Genetics, 2015 Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric
Romina Burla +15 more
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Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
Nature Communications, 2017 Human telomeres are protected by a specialized shelterin complex composed of six proteins. Here the authors structurally characterize the interaction between the POT1-TPP1 shelterin component and identify mutations associated with genome instability and ...
Cong Chen +19 more
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Telomere Dysfunction in Chronic Lymphocytic Leukemia
Frontiers in Oncology, 2021 Telomeres are nucleprotein structures that cap the chromosomal ends, conferring genomic stability. Alterations in telomere maintenance and function are associated with tumorigenesis.
Billy Michael Chelliah Jebaraj +2 more
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Novel Mutation of the TINF2 Gene in a Patient with Dyskeratosis Congenita
Case Reports in Dermatology, 2015 Dyskeratosis congenita (DKC) is a rare inherited disease that is characterized by abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia. DKC is caused by an abnormality in a component of the telomerase and shelterin complexes.
Benjaporn Panichareon +5 more
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Frontiers in Genetics, 2022 Telomere biology disorders (TBDs) induced by TINF2 mutations manifest clinically with a spectrum of phenotypes, from silent carriers to a set of overlapping conditions. A rare TINF2 frameshift mutation (c.591delG) encoding a truncated mutant TIN2 protein
Hai-Long Ren +7 more
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Shelterin: the protein complex that shapes and safeguards human telomeres [PDF]
Genes & Development, 2005 Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific proteins associates with this sequence and protects chromosome ends. By analogy to other chromosomal protein complexes such as condensin and cohesin, I will refer to this complex as shelterin.
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Briefings in Bioinformatics, 2021 Abstract Shelterin, a protective complex at telomeres, plays essential roles in cancer. In addition to maintain telomere integrity, shelterin functions in various survival pathways. However, the detailed mechanisms of shelterin regulation in cancer remain elusive.
Zhenhua Luo +4 more
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