Results 31 to 40 of about 4,729 (146)

Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex. [PDF]

J Mol Biol, 2017
The shelterin complex is a macromolecular assembly of proteins that binds to and protects telomeric DNA, which composes the ends of all linear chromosomes. Shelterin proteins prevent chromosome ends from fusing together and from eliciting erroneous induction of DNA damage response pathways.
Scott H, Kim JK, Yu C, Huang L, Qiao F, Taylor DJ.   +5 more
europepmc   +6 more sources

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment. [PDF]

PLoS Genetics, 2014
In both fission yeast and humans, the shelterin complex plays central roles in regulation of telomerase recruitment, protection of telomeres against DNA damage response factors, and formation of heterochromatin at telomeres.
Jennifer L Harland, Ya-Ting Chang, Bettina A Moser, Toru M Nakamura   +3 more
doaj   +1 more source

Shelterin complex and associated factors at human telomeres. [PDF]

Nucleus, 2011
The processes regulating telomere function have major impacts on fundamental issues in human cancer biology. First, active telomere maintenance is almost always required for full oncogenic transformation of human cells, through cellular immortalization by endowment of an infinite replicative potential.
Diotti R, Loayza D.
europepmc   +4 more sources

Characterization of the DNA binding specificity of Shelterin complexes [PDF]

Nucleic Acids Research, 2011
The Shelterin complex associates with telomeres and plays an essential role in telomere protection and telomerase regulation. In its most abundant form, the complex is composed of six core components: TRF1, TRF2, POT1, TIN2, TPP1 and RAP1. Of these subunits, three can interact directly with either single-stranded (POT1) or double-stranded (TRF1, TRF2 ...
Choi, Kyung H., Farrell, Amy S., Lakamp, Amanda S., Ouellette, Michel M.   +3 more
openaire   +2 more sources

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

eLife, 2023
The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive.
Léonard Colin, Celine Reyes, Julien Berthezene, Laetitia Maestroni, Laurent Modolo, Esther Toselli, Nicolas Chanard, Stephane Schaak, Olivier Cuvier, Yannick Gachet, Stephane Coulon, Pascal Bernard, Sylvie Tournier   +12 more
doaj   +1 more source

The structural biology of the shelterin complex [PDF]

Biological Chemistry, 2018
Abstract The shelterin complex protects telomeric DNA and plays critical roles in maintaining chromosome stability. The structures and functions of the shelterin complex have been extensively explored in the past decades. This review summarizes the current progress on structural studies of shelterin complexes from different species.
openaire   +2 more sources

Canine sperm motility is associated with telomere shortening and changes in expression of shelterin genes

BMC Veterinary Research, 2023
Background Motion quality is a critical property for essential functions. Several endogenous and exogenous factors are involved in sperm motility. Here, we measured the relative telomere length and evaluated the gene expression of its binding-proteins ...
Hossein Hassanpour, Pezhman Mirshokraei, Marzieh Salehpour, Khadije Amiri, Parvin Ghareghani, Leila Nasiri   +5 more
doaj   +1 more source

ZNF524 directly interacts with telomeric DNA and supports telomere integrity

Nature Communications, 2023
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex blocks unwanted DNA damage repair at telomeres, e.g. by
Hanna Braun, Ziyan Xu, Fiona Chang, Nikenza Viceconte, Grishma Rane, Michal Levin, Liudmyla Lototska, Franziska Roth, Alexia Hillairet, Albert Fradera-Sola, Vartika Khanchandani, Zi Wayne Sin, Wai Khang Yong, Oliver Dreesen, Yang Yang, Yunyu Shi, Fudong Li, Falk Butter, Dennis Kappei   +18 more
doaj   +1 more source

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita. [PDF]

Blood, 2007
Abstract Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome characterized by the triad of abnormal nails, lacey reticular skin pigmentation, and oral leukoplakia. Patients with DC are at high risk of developing aplastic anemia, myelodysplastic syndrome and leukemia.
Savage, Sharon A, Giri, Neelam, Baerlocher, Gabriela M, Orr, Nick, Lansdorp, Peter M, Alter, Blanche P   +5 more
openaire   +5 more sources

Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders. [PDF]

PLoS ONE, 2015
Telomerase, shelterin proteins and various interacting factors, named non-shelterin proteins, are involved in the regulation of telomere length (TL). Altered expression of any of these telomere-associated genes can lead to telomere dysfunction, causing ...
Julieta Panero, Flavia Stella, Natalia Schutz, Dorotea Beatriz Fantl, Irma Slavutsky   +4 more
doaj   +1 more source