Results 81 to 90 of about 4,795 (186)
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT Neuronal ceroid lipofuscinosis type 2 (CLN2) disease, a lysosomal storage disorder, causes early childhood psychomotor regression, vision loss, seizures, and rapid progressive gray matter loss. However, the link between neurodegenerative processes induced by lysosomal pathophysiology and the clinical phenotype remains unclear.
Marvin Petersen +12 more
wiley +1 more source
Oncology Reports, 2016 Regulatory factor X-5 (RFX5) was previously characterized as an essential and highly specific regulator of major histocompatibility class II (MHCII) gene expression in the immune system. We found that RFX5 is significantly upregulated in hepatocellular carcinoma (HCC) tumors and cell lines compared with non-tumor tissues in mRNA expression levels, but ...
Yangjing, Zhao +9 more
openaire +3 more sources
Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.ABSTRACT Glioblastoma (GBM) is an aggressive brain tumour with an immunosuppressive environment and poor prognosis; however, the roles of mitophagy and oxidative stress in its prognosis remain underexplored. This study analysed multi‐omics data from TCGA‐GBM (n = 168) and two GEO cohorts (GSE43378, n = 50; GSE147352, n = 85), compiling 603 mitophagy ...
Changjiang He +2 more
wiley +1 more source
Aggregate, Volume 7, Issue 3, March 2026.The multi‐component doping strategy, involving self‐assembly, host‐guest systems, and crystal engineering, has gained attention for its simplicity, cost‐effectiveness, structural diversity, and adjustable room‐temperature phosphorescence (RTP). This review summarizes and evaluates the progress in creating RTP materials using this strategy, highlighting
Zhenjie Zhou +10 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 3, Page 1635-1648, March 2026.ABSTRACT As the staple food of over half the world's population, rice with a high resistant starch (RS) content may be beneficial in the dietary prevention of diabetes and hyperlipidemia. Mutating key enzymes in starch metabolism to increase the RS content has been successful in other crops.
Qingqing Yang +5 more
wiley +1 more source
Cell Reports, 2015 Shelterin, a six-member complex, protects telomeres from nucleolytic attack and regulates their elongation by telomerase. Here, we have developed a strategy, called MICro-MS (Mapping Interfaces via Crosslinking-Mass Spectrometry), that combines ...
Jinqiang Liu +8 more
doaj +1 more source
Advanced Science, Volume 13, Issue 12, 27 February 2026.Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han +16 more
wiley +1 more source
POT1–TPP1 Binding and Unfolding of Telomere DNA Discriminates against Structural Polymorphism [PDF]
Journal of Molecular Biology, 2016 Telomeres are nucleoprotein complexes that reside at the ends of linear chromosomes and help maintain genomic integrity. Protection of telomeres 1 (POT1) and TPP1 are telomere-specific proteins that bind as a heterodimer to single-stranded telomere DNA to prevent illicit DNA damage responses and to enhance telomerase-mediated telomere extension ...
Michael R, Mullins +6 more
openaire +2 more sources
Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu +4 more
wiley +1 more source
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly [PDF]
Proceedings of the National Academy of Sciences, 2006 Mammalian telomeric proteins function through dynamic interactions with each other and telomere DNA. We previously reported the formation of a high-molecular-mass telomeric complex (the mammalian telosome) that contains the six core proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 (formerly named PTOP/PIP1/TINT1) and mediates telomere end-capping and ...
Matthew S, O'Connor +4 more
openaire +2 more sources