Results 61 to 70 of about 4,429 (159)
Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer
, 2017 Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension. However, how POT1 interacts with TPP1 remains unknown. Here we present the crystal structure of the C-
Xianyun Chen +19 more
core +1 more source
Human Mutation, Volume 2026, Issue 1, 2026.This study integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics (ST), and bulk transcriptomics data from public databases to create a comprehensive map of the immune microenvironment in hepatocellular carcinoma (HCC). Cell communication analysis revealed the pivotal role of macrophages in the HCC tumor microenvironment (TME ...
Xiushen Li +10 more
wiley +1 more source
, 2016 The CLN2 form of neuronal ceroid lipofuscinosis is a neurodegenerative disease that results from mutations in the TPP1 gene. Affected children exhibit progressive declines in most neurological functions including vision.
Williamson, Baye G. +10 more
core +1 more source
, 2013 Radiotherapy is one of the major therapeutic strategies in cancer treatment. The telomere-binding protein TPP1 is an important component of the shelterin complex at mammalian telomeres.
Han Lei +12 more
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, 2012 Tpp1(−/−) mice were administered unmodified enzyme or vehicle alone via tail vein injection and tissues collected after 24 hours. Tissue processing and immunostaining was conducted as described previously [33].
Istvan Sohar (152558) +4 more
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A mechanistic study of POT1-TPP1 mediated human telomerase processivity
, 2009 Telomerase contributes to telomere replication by synthesizing repeats of DNA, and two telomeric DNA-binding proteins, POT1 and TPP1, synergistically increase its repeat addition processivity.
Latrick, Chrysa Marie
core
Effects of TPP1 overexpression on the radiosensitivity and cell cycle in HCT116 cells.
, 2013 (A)Verification of TPP1 overexpression by western blotting. (B) HCT116-Mock and-TPP1 cells were irradiated with X-rays and then cell survival was determined using clonogenic assay.
Wenbo Wang (300277) +12 more
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, 2013 (A) TPP1 production was detected by western blotting.. (B) Telomere length was examined by Southern blot analysis. (C) Relative TPP1 production, radiosensitivity (SF2) and telomere length (TRF) in human colorectal cancer cell lines.
Wenbo Wang (300277) +12 more
core +1 more source
Telomere Protection by TPP1 Is Mediated by POT1a and POT1b
, 2009 Mammalian telomeres are protected by the shelterin complex, which contains single-stranded telomeric DNA binding proteins (POT1a and POT1b in rodents, POT1 in other mammals).
Catherine E. Keegan +3 more
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Different Faces of the Human Telomeric Protein TPP1
, 2019 Eukaryotic cells must overcome two major biological problems associated with linear chromosomes: the end protection and the end replication problems. The end protection problem occurs when the natural ends of linear chromosomes are misrecognized as DNA ...
Grill, Sherilyn
core