Results 71 to 80 of about 4,429 (159)

Abstract 5745: Study on telomere shelterin component TPP1 in esophageal squamous cell carcinoma

, 2017
Esophageal cancer (EC) is one of the most aggressive cancer and ranks the sixth leading cause of cancer-related mortality worldwide, approximately 70% of global esophageal carcinoma cases occur in China and esophageal squamous cell carcinoma (ESCC) is ...
Jiajing Cai, Ru Sun, Lei Xu, Qiang Ma, Guangcheng Huang, Xiaolan Guo, Jiang Zou, Lihua Yao, Mayong Fu   +8 more
core   +1 more source

Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum [PDF]

, 2015
Neuronal ceroid lipofuscinosis (NCL) is the most common childhood-onset neurodegenerative disease. NCL is inevitably fatal, and there is currently no treatment available.
Phillips, Jonathan E., Richard H. Gomer, Gomer, Richard H., Jonathan E. Phillips   +3 more
core   +1 more source

TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice.

, 2010
The TPP1/ACD protein (hereafter TPP1) is a component of the shelterin complex at mammalian telomeres. Here we find that Tpp1-deficient mouse embryonic fibroblasts (MEFs) show increased chromosomal instability including sister chromatid fusions and ...
Maria A. Blasco, Paula Martinez, Tejera, AM, Thanasoula, M, Chunyan Liao, Martinez, P, Maria Thanasoula, Stagno d'Alcontres, M, Madalena Tarsounas, Marion, Rosa M., Rosa M. Marion, Juana M. Flores, Tejera, Agueda M., Blasco, Maria A., Liao, Chunyan, Flores, Juana M., Martina Stagno d'Alcontres, Agueda M. Tejera, Thanasoula, Maria, Flores, JM, Liao, C, Tarsounas, Madalena, Martinez, Paula, Stagno d'Alcontres, Martina, Marion, RM, Blasco, MA   +25 more
core   +1 more source

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation [PDF]

, 2018
Telomere length homeostasis is essential for the long-term survival of stem cells, and its set point determines the proliferative capacity of differentiated cell lineages by restricting the reservoir of telomeric repeats.
Lai, Christine S., Regalado, Samuel G., Collins, Kathleen, Hockemeyer, Dirk, Cost, Gregory J., Jaenisch, Rudolf, O’Neil, Colleen M., Gregory, Philip D., Sexton, Alec N., Urnov, Fyodor D.   +9 more
core   +1 more source

Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis

, 2015
The CLN2 form of neuronal ceroid lipofuscinosis, a type of Batten disease, is a lysosomal storage disorder caused by a deficiency of the enzyme tripeptidyl peptidase-1 (TPP1).
Kennedy, Derek, Butt, Mark T., Cooper, Jonathan D., Adams, Eric L., Wong, Andrew M S, Johnson, Gayle C., Henshaw, Joshua, Katz, Martin L., Keve, Steve, O'Neill, Charles A., Doeleman, Thom, Cahayag, Rhea, Reed, Randall P., Musson, Donald G., Sri, Sarmi, Coates, Joan R., Tsuruda, Laurie S., Vuillemenot, Brian R.   +17 more
core   +1 more source

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

, 2019
Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported.
Haney, M.J., Batrakova, E.V., Harrison, E.B., Klyachko, N.L., Kabanov, A.V., Zhao, Y.   +5 more
core   +2 more sources

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

, 2012
SummaryTelomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres through interactions with telomere-binding proteins. Here, we show that the OB-fold domain
Zhong, Franklin L., Pech, Matthew F., Freund, Adam, Artandi, Steven E., Batista, Luis F.Z., Venteicher, Andrew S.   +5 more
core   +1 more source

TPP1 overexpression inhibits IR induced apoptosis.

, 2013
HCT116-Mock and-TPP1 cells were irradiated with 5 Gy X-ray and incubated for 24h. The percentage of apoptotic cells was measured by flow cytometry. (A) Representative results of diffrerent groups are shown.
Wenbo Wang (300277), Haijun Yu (417023), Yunfeng Zhou (417027), Zheng Li (26302), Liu Hu (417021), Xiaoxi Yang (486981), Hui Yang (91136), Han Lei (417024), ZhengKai Liao (5656954), Lei Yang (102719), Fuxiang Zhou (417026), Juan Zhong (486982), Conghua Xie (282964)   +12 more
core   +1 more source

TPP1 overexpression promotes repair of DNA damage and telomere dysfunction induced by irradiation.

, 2013
HCT116-Mock and -TPP1 were exposed to 1 Gy IR and incubated at indicated time points.. Results are based on three independent experiments with on average 100 cell nuclei analyzed per experiment per point.
Wenbo Wang (300277), Haijun Yu (417023), Yunfeng Zhou (417027), Zheng Li (26302), Liu Hu (417021), Xiaoxi Yang (486981), Hui Yang (91136), Han Lei (417024), ZhengKai Liao (5656954), Lei Yang (102719), Fuxiang Zhou (417026), Juan Zhong (486982), Conghua Xie (282964)   +12 more
core   +1 more source

M6P content of TPP1 fusion proteins.

, 2014
CHO cells were transiently transfected with the indicated constructs. The media samples collected at the two time points as in Fig. 6 were pooled and used for MPR-affinity chromatography.
Ling Huang (51752), David E. Sleat (152563), Douglas Pike (526096), Vikas Nanda (172915), Peter Lobel (152571)   +4 more
core   +1 more source