Results 91 to 100 of about 4,795 (186)
Small, Volume 22, Issue 11, 20 February 2026.This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack +9 more
wiley +1 more source
Identification of human TERT elements necessary for telomerase recruitment to telomeres
eLife, 2014 Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch,
Jens C Schmidt +2 more
doaj +1 more source
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source
BMC Neurology, 2018 Background Neuronal ceroid lipofuscinoses type I and type II (NCL1 and NCL2) also known as Batten disease are the commonly observed neurodegenerative lysosomal storage disorder caused by mutations in the PPT1 and TPP1 genes respectively.
Jayesh Sheth +12 more
doaj +1 more source
Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins
Aging Cell, Volume 25, Issue 2, February 2026.We characterized the plasma proteomic profiles of centenarians from the SWISS100 cohort, identifying 583 differentially expressed proteins compared to younger and geriatric groups. Cross‐validation with the independent datasets NECS and the TAME consortium confirmed a robust aging signature, while fractional polynomial regressions revealed a specific ...
Flavien Delhaes +8 more
wiley +1 more source
Biodistribution of TPP1 preparations 24 hours following IV administration.
, 2012 *Only 82% of the oxidized proTPP1 could be autocatalytically converted to active enzyme. The dose represents total proenzyme based on concentration as determined by absorbance measurements, while % of injected activity recovered from all tissues analyzed
Istvan Sohar (152558) +4 more
core +1 more source
Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.ABSTRACT Natural‐history datasets have become pivotal for drug development and for shaping clinical‐practice guidelines in rare diseases, yet many lysosomal storage disorders would benefit from deep phenotyping and modern analytic methods. Our objective was to integrate the past decade of genomic, cellular, treatment‐outcome, and regulatory advances ...
Noor Ul Ain +2 more
wiley +1 more source
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection
, 2011 The mammalian shelterin component TPP1 has essential roles in telomere maintenance and, together with POT1, is required for the repression of DNA damage signaling at telomeres.
Ju-Mei Li +17 more
core +1 more source
TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. [PDF]
, 2010 The TPP1/ACD protein (hereafter TPP1) is a component of the shelterin complex at mammalian telomeres. Here we find that Tpp1-deficient mouse embryonic fibroblasts (MEFs) show increased chromosomal instability including sister chromatid fusions and ...
Maria A. Blasco +25 more
core +1 more source
In vitro stability of TPP1 preparations in tissue extracts.
, 2012 Activated TPP1 was mixed with either brain or liver extracts (20 and 10 mg tissue wet weight/mL, respectively) from Tpp1(−/−) mice (final concentration 0.06 mg/mL TPP1, 90% tissue extracts in 150 mM sodium chloride, 100 mM sodium acetate pH 4.5, 0.1 ...
Istvan Sohar (152558) +4 more
core +1 more source