Results 41 to 50 of about 4,429 (159)

Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading‐strand replication [PDF]

The EMBO Journal, 2011
Eukaryotic up-frameshift 1 (UPF1) is a nucleic acid-dependent ATPase and 5'-to-3' helicase, best characterized for its roles in cytoplasmic RNA quality control. We previously demonstrated that human UPF1 binds to telomeres in vivo and its depletion leads to telomere instability. Here, we show that UPF1 is present at telomeres at least during S and G2/M
Chawla Raghav, Redon Sophie, Raftopoulou Christina, Wischnewski Harry, Gagos Sarantis, Azzalin Claus M   +5 more
openaire   +3 more sources

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension

Nucleic Acids Research, 2023
Abstract CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and is required for multiple steps in telomere replication, including termination of G-strand extension by telomerase and synthesis of the complementary C-strand.
Huan Wang, Tengfei Ma, Xiaotong Zhang, Wei Chen, Yina Lan, Guotao Kuang, Shih-Jui Hsu, Zibin He, Yuxi Chen, Jason Stewart, Anukana Bhattacharjee, Zhenhua Luo, Carolyn Price, Xuyang Feng   +13 more
openaire   +2 more sources

Recurrent TPP1 Promoter Mutations Drive Telomere Maintenance in Melanoma

, 2023
Limitless replicative potential is a defining hallmark of cancer. Somatic cells are limited in their replicative potential by telomere shortening. Telomeres are caps on the ends of chromosomes that shorten as cells divide.
Chun-on, Pattra
core  

TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma

Science, 2022
Overcoming replicative senescence is an essential step during oncogenesis, and the reactivation of TERT through promoter mutations is a common mechanism. TERT promoter mutations are acquired in about 75% of melanomas but are not sufficient to maintain telomeres, suggesting that additional ...
Pattra Chun-on, Angela M. Hinchie, Holly C. Beale, Agustin A Gil Silva, Elizabeth Rush, Cindy Sander, Carla J. Connelly, Brittani K.N. Seynnaeve, John M. Kirkwood, Olena M. Vaske, Carol W. Greider, Jonathan K. Alder   +11 more
openaire   +4 more sources

The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma

Oncology Reports, 2016
Regulatory factor X-5 (RFX5) was previously characterized as an essential and highly specific regulator of major histocompatibility class II (MHCII) gene expression in the immune system. We found that RFX5 is significantly upregulated in hepatocellular carcinoma (HCC) tumors and cell lines compared with non-tumor tissues in mRNA expression levels, but ...
Yangjing, Zhao, Xingwang, Xie, Weijia, Liao, Henghui, Zhang, Hui, Cao, Ran, Fei, Xueyan, Wang, Lai, Wei, Qixiang, Shao, Hongsong, Chen   +9 more
openaire   +3 more sources

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, Volume 22, Issue 11, 20 February 2026.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Expression of TPP1 fusion proteins.

, 2014
CHO cells were transiently transfected as indicated. Media was collected at 24) TPP1 and β-galactosidase activity measured in media and cell lysates. Data represents total activity in media (24 and 48-hour collection points) and cells.
Ling Huang (51752), David E. Sleat (152563), Douglas Pike (526096), Vikas Nanda (172915), Peter Lobel (152571)   +4 more
core   +1 more source

Nonsense-Mutationen des TPP1-Gens bei cLINCL: Potential der Readthrough-Therapie

, 2021
Die Tripeptidylpeptidase 1 (TPP1) ist eine lysosomale Serinprotease, die Tripeptide am N-Terminus von Polypeptiden abspaltet und somit an deren Abbau beteiligt ist. TPP1 wird als inaktives Proenzym synthetisiert und hat als solches eine Molekülmasse von
Kramer, Vivian
core   +2 more sources