Results 41 to 50 of about 4,795 (186)

A Rare Variant P507L in TPP1 Interrupts TPP1–TIN2 Interaction, Influences Telomere Length, and Confers Colorectal Cancer Risk in Chinese Population [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2018
Abstract Background: Telomere dysfunction triggers cellular senescence and constitutes a driving force for cancer initiation. Genetic variants in genes involved in telomere maintenance may contribute to colorectal cancer susceptibility.
Jiaoyuan, Li, Jiang, Chang, Jianbo, Tian, Juntao, Ke, Ying, Zhu, Yang, Yang, Yajie, Gong, Danyi, Zou, Xiating, Peng, Nan, Yang, Shufang, Mei, Xiaoyang, Wang, Liming, Cheng, Weiguo, Hu, Jing, Gong, Rong, Zhong, Xiaoping, Miao   +16 more
openaire   +2 more sources

EMSA analysis of the binding affinity of the POT1-TPP1-TIN2(1–354) complex for various telomeric sequence constructs.

, 2022
The various 32P-labelled telomeric DNAs were incubated alone (−) or with increasing quantities (10 pM to 100 nM) of POT1-TPP1-TIN2(1–354) protein complex. The binding reaction products were separated by native PAGE.
Simon Lattmann (540093), Daniela Rhodes (11349461), Emmanuel W. Smith (1576297), Zhehui Barry Liu (12101806), Bilal Ahsan (12101809)   +4 more
core   +1 more source

A new mutant at the end: TPP1, telomeres, and BMF [PDF]

Blood, 2014
In this issue of Blood, Guo et al identify a mutation in ACD, which encodes the protein TPP1, as the underlying cause of short telomeres and bone marrow failure (BMF) in a family.1 They show that the mutation results in a defect in the recruitment of telomerase to telomeres.
openaire   +2 more sources

Systemic administration of tripeptidyl peptidase I in a mouse model of late infantile neuronal ceroid lipofuscinosis: effect of glycan modification. [PDF]

PLoS ONE, 2012
Late-infantile neuronal ceroid lipofuscinosis (LINCL) is a recessive genetic disease of childhood caused by deficiencies in the lysosomal protease tripeptidyl peptidase I (TPP1). Disease is characterized by progressive and extensive neuronal death.
Yu Meng, Istvan Sohar, Lingling Wang, David E Sleat, Peter Lobel   +4 more
doaj   +1 more source

TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway

Frontiers in Cell and Developmental Biology, 2020
BackgroundPoor cell survival after transplantation restricts the therapeutic potential of mesenchymal stem cell (MSC) transplantation into infarcted hearts, particularly in older individuals. TPP1, a component of the shelterin complex that is involved in
Kaixiang Yu, Kaixiang Yu, Zhiru Zeng, Zhiru Zeng, Si Cheng, Si Cheng, Wangxing Hu, Wangxing Hu, Chenyang Gao, Chenyang Gao, Feng Liu, Feng Liu, Jinyong Chen, Jinyong Chen, Yi Qian, Yi Qian, Dilin Xu, Dilin Xu, Jing Zhao, Jing Zhao, Xianbao Liu, Xianbao Liu, Jian’an Wang, Jian’an Wang   +23 more
doaj   +1 more source

Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment [PDF]

Proceedings of the National Academy of Sciences, 2013
Telomere maintenance is essential for organisms with linear chromosomes and is carried out by telomerase during cell cycle. The precise mechanism by which cell cycle controls telomeric access of telomerase and telomere elongation in mammals remains largely unknown.
Yi, Zhang, Liuh-Yow, Chen, Xin, Han, Wei, Xie, Hyeung, Kim, Dong, Yang, Dan, Liu, Zhou, Songyang   +7 more
openaire   +2 more sources

Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated Telomere Deprotection

Cells, 2022
While mitochondrial bioenergetic deregulation has long been implicated in cellular senescence, its mechanistic involvement remains unclear. By leveraging diverse mitochondria-related gene expression profiles derived from two different cellular senescence models of human diploid fibroblasts, we found that the expression of mitoribosomal proteins (MRPs ...
Seongki Min, So Mee Kwon, Jiwon Hong, Young-Kyoung Lee, Tae Jun Park, Su Bin Lim, Gyesoon Yoon   +6 more
openaire   +3 more sources

Modelling of Neuronal Ceroid Lipofuscinosis Type 2 in Dictyostelium discoideum Suggests That Cytopathological Outcomes Result from Altered TOR Signalling

Cells, 2019
The neuronal ceroid lipofuscinoses comprise a group of neurodegenerative disorders with similar clinical manifestations whose precise mechanisms of disease are presently unknown.
Paige K. Smith, Melodi G. Sen, Paul R. Fisher, Sarah J. Annesley   +3 more
doaj   +1 more source

Tripeptidyl peptidase I promotes human endometrial epithelial cell adhesive capacity implying a role in receptivity

Reproductive Biology and Endocrinology, 2020
The endometrium undergoes cyclic remodelling throughout the menstrual cycle in preparation for embryo implantation which occurs in a short window during the mid-secretory phase.
Leilani L. Santos, Cheuk Kwan Ling, Evdokia Dimitriadis   +2 more
doaj   +1 more source

Modern genome editing meets telomeres: the many functions of TPP1 [PDF]

Genes & Development, 2014
The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.
openaire   +2 more sources