Results 101 to 110 of about 18,483 (234)

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

The Technology Proficiency Self-Assessment Questionnaire (TPSA)

, 2015
The Technology Proficiency Self-Assessment (TPSA) questionnaire has been used for 15 years in the USA and other nations as a self-efficacy measure for proficiencies fundamental to effective technology integration in the classroom learning environment. Internal consistency reliabilities for each of the five-item scales have typically ranged from .73 to .
Christensen, Rhonda, Knezek, Gerald
openaire   +1 more source

Predicting prostate biopsy outcome: Prostate health index (phi) and prostate cancer antigen 3 (PCA3) are useful biomarkers [PDF]

, 2012
Indication for prostate biopsy is presently mainly based on prostate-specific antigen (PSA) serum levels and digital-rectal examination (DRE). In view of the unsatisfactory accuracy of these two diagnostic exams, research has focused on novel markers to ...
A. D. Carlo, A. Mariano, A. Marino, A. Sorrentino, BRUZZESE, DARIO, C. Buonerba, C. Mazzarella, G. D. Lorenzo, M. Ferro, R. Autorino, S. Perdonà, TERRACCIANO, DANIELA, V. Altieri, V. Macchia   +13 more
core   +1 more source

复合型PSA与总PSA比值在前列腺癌诊断中的应用

Zhongguo shiyan zhenduanxue, 2005
目的　探讨复合型PSA（CPSA）与总PSA（TPSA）比值在前列腺癌（PCa）诊断的应用价值。方法　采用化学发光免疫分析法（CLIA）测定2 78例患者（其中PCa 6 3例,BPH2 15例）与112例正常健康体检男性的血清TPSA、CPSA水平,并计算TPSA/CPSA（C/T）比值。结果　BPH组、PCa组TPSA、CPSA水平均显著高于正常对照组（P
陈斌鸿, 陈社安
doaj  

Discordant prostate specific antigen test results despite WHO assay standardization

The International Journal of Biological Markers, 2018
Introduction: Total PSA (tPSA) and free PSA (fPSA) are the most commonly used biomarkers for early detection of prostate cancer. Despite standardization efforts, many available PSA assays may still produce discordant results.
Martin Boegemann, Christian Arsov, Boris Hadaschik, Kathleen Herkommer, Florian Imkamp, Jerzy-Roch Nofer, Joachim Gerß, Peter Albers, Axel Semjonow   +8 more
doaj   +1 more source

An investigation into reducing the spindle acceleration energy consumption of machine tools [PDF]

, 2016
Machine tools are widely used in the manufacturing industry, and consume large amount of energy. Spindle acceleration appears frequently while machine tools are working. It produces power peak which is highly energy intensive. As a result, a considerable
Jia, Shun, Liu, Ying, Lv, Jingxiang, Tang, Renzhong, Tang, Wangchujun, Zhang, Yingfeng   +5 more
core   +2 more sources

Elevation of Serum Prostate-Specific Antigen Levels in Males With Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis
Hypoxemia is a clinical characteristic of pulmonary embolism (PE). Hypoxemia is associated with variations in serum prostate-specific antigen (PSA) levels.
You-Fan Peng MD, PhD, Li-Ya Ma BS, Miao Luo BS   +2 more
doaj   +1 more source

Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors. [PDF]

, 2017
The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the PB2 protein sequence ...
Kukol, A., Kukol, A., Patel, H., Patel, H.   +3 more
core   +3 more sources

PENCEMARAN AIR DI KAWASAN TEMPAT PEMBUANGAN SAMPAH AKHIR (TPSA) CIANGIR KOTA TASIKMALAYA

NATURALISTIC : Jurnal Kajian Penelitian Pendidikan dan Pembelajaran, 2018
Air sebagai komponen dari lingkungan hidup yang akan mempengaruhi dan dipengaruhi oleh komponen lainnya. Semua makhluk hidup membutuhkan air untuk mempertahankan hidup. Namun, dalamkenyataannya air yang berada di badan penerima air TPSA seperti sungai mulai beralih fungsi dan mengalami pencemaran. Penelitian ini bertujaun untuk menganalis akualitas air
Ruli Hidayat, Rani Rani, Fauziah Rachman, Ai Irnawati, Dede Suyanti, Cecep Cecep   +5 more
openaire   +1 more source

Neutrophil-and-monocyte-to-lymphocyte ratio is positively associated with elevated prostate-specific antigen levels and high-risk prostate cancer: evidence from the NHANES (2003–2008)

Frontiers in Cell and Developmental Biology
IntroductionProstate cancer (PCa) is a prevalent malignancy in men globally. The total prostate-specific antigen (TPSA) test is essential for PCa screening.
Shang Gao, Shang Gao, Ping Jiang, Renli Tian   +3 more
doaj   +1 more source