Results 71 to 80 of about 2,852 (191)

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Association of Trabecular Bone Score-Adjusted Fracture Risk Assessment Tool with Coronary Artery Calcification in Women

Diagnostics, 2022
The trabecular bone score (TBS) was found to be significantly associated with moderate coronary artery calcification (CAC). The aim of this study was to further explore the association between TBS-adjusted Fracture Risk Assessment Tool (FRAX) and CAC ...
Tzyy-Ling Chuang, Yuh-Feng Wang, Malcolm Koo, Mei-Hua Chuang   +3 more
doaj   +1 more source

Next‐Generation Paleopathology: Using Commercial AI in Bioarchaeological Diagnosis

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics.
Jessica Mongillo, Giulia Vescovo, Giulia Manzo, Nicoletta Zedda, Barbara Bramanti   +4 more
wiley   +1 more source

The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength. [PDF]

, 2015
Trabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis.
Eastell, Richard, Yongtao Lu, Lu, Yongtao, Yang, L., Lippuner, Kurt, Yan Chevalier, Maquer, G., Ghislain Maquer, Matthias Krause, Eastell, R., Dall'Ara, Enrico, Enrico Dall'Ara, Chevalier, Y., Krause, Matthias, Lu, Y., Maquer, Ghislain Bernard, Philippe K Zysset, Dall'Ara, E., Krause, M., Zysset, P.K., Zysset, Philippe, Richard Eastell, Kurt Lippuner, Chevalier, Yan, Lang Yang, Yang, Lang, Lippuner, K.   +26 more
core   +1 more source

Association of mental disorders and psychotropic medications with bone texture as measured with trabecular bone score.

, 2022
Mental disorders and psychotropic medications are known to increase the risk of osteoporosis and fractures. However, current evidence is mostly limited to studies that used bone mineral density (BMD), which does not provide information about the texture ...
Lix, L.M., Hans, D., Bolton, J.M., Leslie, W.D., Hafizi, S.   +4 more
core   +1 more source

Prevalence of Poor Bone Quality in Patients Undergoing Spine Surgery: A Comprehensive Approach

Global Spine Journal, 2022
Study Design: A cross-sectional study. Objectives: To investigate the prevalence of poor bone quality in patients requiring spine surgery through comprehensive evaluation with bone mass density (BMD), trabecular bone score (TBS), FRAX, and vitamin D ...
Ricardo Díaz-Romero Paz MD, Manuel Sosa Henríquez PhD, Kevin Armas Melián MD, Claudia Balhen Martin MD   +3 more
doaj   +1 more source

Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway

Phytotherapy Research, EarlyView.
Under iron overload conditions, curcumin inhibits cellular senescence and promotes osteogenic differentiation by activating the NRF2/GPX4 signaling pathway in bone marrow mesenchymal stem cells (BMSCs), thereby preventing the onset of osteoporosis. ABSTRACT Dysregulated proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs ...
Jingmin Che, Qing Feng, Zhixia Zhao, Jingying Sun, Weihao Ren, Yangmeng Feng, Cuixiang Xu, Xu‐Hui Li   +7 more
wiley   +1 more source

Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image [PDF]

, 2014
The trabecular bone score (TBS) is a gray-level textural metric that can be extracted from the two-dimensional lumbar spine dual-energy X-ray absorptiometry (DXA) image.
Bilezikian, J.P., Barbara C Silva, McCloskey, E. V., Binkley, N., Eugene V McCloskey, Leslie, W.D., Heinrich Resch, Lamy, O., Silva, B. C., William D Leslie, John A Kanis, Lesnyak, O., Olivier Lamy, Silva, B.C., Olga Lesnyak, Neil Binkley, McCloskey, E.V., Resch, H., Bilezikian, J. P., Leslie, W. D., Kanis, J.A., Kanis, J. A., John P Bilezikian   +22 more
core   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source

Trabecular bone score (TBS) is associated with sub-clinical vertebral fractures in HIV-infected patients

, 2017
Fragility fractures risk is increased among HIV infected patients. Bone microstructure alterations, in addition to bone mineral density (BMD) reduction, might be responsible for the increased risk. The aim of this study was to determine the prevalence of
Argento, G., ACETI, Antonio, D. Novarini, G. Argento, E. Teti, Novarini, D., F. G. Conti, A. Aceti, Ciullini, Lorenzo, PENNICA, Alfredo, TETI, ELISABETTA, Lorenzo Ciullini, CONTI, Francesco, PUGLIESE, Giuseppe, G. Pugliese, A. Pennica   +15 more
core   +1 more source