Results 31 to 40 of about 78,864 (334)
Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. [PDF]
PLoS ONE, 2016 Exosomes are emerging as important mediators of cell-matrix interactions by means of specific adhesion proteins. Changes in the tissue-specific exosomal protein expression may underlie pathological conditions whereby extracellular matrix turnover and ...
W Michael Dismuke +2 more
doaj +1 more source
The Role of Integrins in the Trabecular Meshwork [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2014 Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). However, integrins are not just adhesion receptors. They can act as "bidirectional signal transducers" that coordinate a large number of cellular activities in response to the extracellular environment and intracellular signaling ...
Debjani, Gagen +3 more
openaire +2 more sources
Human ocular fluid outflow on-chip reveals trabecular meshwork-mediated Schlemm's canal endothelial dysfunction in steroid-induced glaucoma. [PDF]
Nat Cardiovasc ResLu R, Kolarzyk AM, Stamer WD, Lee E.
europepmc +3 more sources
Biomaterials and Biosystems, 2021 Glaucoma is the second leading cause of irreversible blindness worldwide. Glaucoma is a progressive optic neuropathy in which permanent loss of peripheral vision results from neurodegeneration in the optic nerve head.
Devon J. Crouch +4 more
doaj +1 more source
The intrinsic stiffness of human trabecular meshwork cells increases with senescence. [PDF]
, 2015 Dysfunction of the human trabecular meshwork (HTM) plays a central role in the age-associated disease glaucoma, a leading cause of irreversible blindness.
Chang, Yow-Ren +4 more
core +3 more sources
Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow
Journal of Physiology, 2020 Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that regulates intraocular pressure through the control of aqueous humour drainage.
O. Yarishkin +9 more
semanticscholar +1 more source
Aqueous Humor Outflow Structure and Function Imaging At the Bench and Bedside: A Review. [PDF]
, 2016 Anterior segment glaucoma clinical care and research has recently gained new focus because of novel imaging modalities and the advent of angle-based surgical treatments. Traditional investigation drawn to the trabecular meshwork now emphasizes the entire
Huang, Alex S +2 more
core +1 more source
Role of MicroRNAs in the Trabecular Meshwork [PDF]
Journal of Ocular Pharmacology and Therapeutics, 2014 MicroRNAs (miRNAs) are now recognized as important post-transcriptional regulators of gene expression. MiRNAs are known to modulate cellular functions relevant to the normal and pathological physiology of the trabecular meshwork (TM) such as cell contraction and extracellular matrix turnover.
Pedro, Gonzalez +4 more
openaire +2 more sources
Cystatin a, a potential common link for mutant myocilin causative glaucoma. [PDF]
PLoS ONE, 2012 Myocilin (MYOC) is a 504 aa secreted glycoprotein induced by stress factors in the trabecular meshwork tissue of the eye, where it was discovered. Mutations in MYOC are linked to glaucoma.
K David Kennedy +3 more
doaj +1 more source