Results 61 to 70 of about 67,374 (288)

Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration

Advanced Functional Materials, EarlyView.
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo, Zaijin Tao, Zhenzhen Dai, Yinghua Gao, Chengzhen Chu, Cunyi Fan, Shen Liu, Xin Ma, Fangchun Jin, Zhengwei You, Jia Jiang   +10 more
wiley   +1 more source

Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K‐Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma

Journal of Cellular and Molecular Medicine, 2019
Glaucoma has been the leading cause of irreversible blindness worldwide. High intraocular pressure (IOP) is a high‐risk factor of glaucoma, repression of which has been the important treatment of glaucoma in clinic.
Junwei Yan, Xuejiao Yang, Xuefei Jiao, Xian Yang, Mingjin Guo, Yun-Qing Chen, Lu Zhan, Wenshi Chen   +7 more
semanticscholar   +1 more source

A Practice Model for Trabecular Meshwork Surgery [PDF]

Archives of Ophthalmology, 2009
Models for practicing ophthalmic surgery are a necessary part of all ophthalmic training. Herein, we describe a method for preparing human donor cadaveric eyes with direct visualization of the anterior chamber angle for practicing trabecular meshwork surgery. This model can be adapted for use with both fresh and formalin-fixed eyes. The use of formalin-
Arthur J. Sit, Sangita P Patel
openaire   +3 more sources

Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants. [PDF]

PLoS ONE, 2011
In recent years, research efforts exploring the possibility of using biomaterial nanoparticles for intravitreous drug delivery has increased significantly. However, little is known about the effect of material properties on intravitreous tissue responses.
Ling Zou, Ashwin Nair, Hong Weng, Yi-Ting Tsai, Zhibing Hu, Liping Tang   +5 more
doaj   +1 more source

TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis

Advanced Healthcare Materials, EarlyView.
A) SLM generates biomimetic bone scaffolds with consistent porosity but varying TPMS‐Gyroid unit cell designs (TG15, TG20, TG25, TG30). B) By enhancing the expression of ITGB1, TPMS‐Gyroid scaffolds can facilitate osteogenic differentiation in BMSCs and promote M2 polarization in macrophages.
Jing Wang, Zenan Huang, Zhenzhong Han, Jing Luan, Zihan Li, Xutong Guo, Dongxu Yang, Yazhou Cui, Jinxiang Han, Duo Xu   +9 more
wiley   +1 more source

Comprehensive bioinformatics analysis of trabecular meshwork gene expression data to unravel the molecular pathogenesis of primary open‐angle glaucoma

Acta ophthalmologica, 2019
Performing bioinformatics analyses using trabecular meshwork (TM) gene expression data in order to further elucidate the molecular pathogenesis of primary open‐angle glaucoma (POAG), and to identify candidate target genes.
I. Liesenborghs, L. Eijssen, M. Kutmon, T. Gorgels, C. Evelo, H. Beckers, C. Webers, J. Schouten   +7 more
semanticscholar   +1 more source

p38 MAP kinase inhibitor suppresses transforming growth factor-β2-induced type 1 collagen production in trabecular meshwork cells.

PLoS ONE, 2015
Glaucoma is an age-related neurodegenerative disease of retinal ganglion cells, and appropriate turnover of the extracellular matrix in the trabecular meshwork is important in its pathology. Here, we report the effects of Rho-associated kinase (ROCK) and
Miyuki Inoue-Mochita, Toshihiro Inoue, Tomokazu Fujimoto, Takanori Kameda, Nanako Awai-Kasaoka, Naoki Ohtsu, Kenichi Kimoto, Hidenobu Tanihara   +7 more
doaj   +1 more source

Isolated anterior-chamber fungal flocculosus in a healthy child with seeding through the trabecular meshwork

TNOA Journal of Ophthalmic Science and Research, 2019
We report a case of isolated anterior-chamber (AC) fungal hyphae in a healthy child following injury with a broomstick with no evidence of obvious intraocular penetration, a rare presentation of isolated traumatic AC mycoses.
Manjula Jayakumar, Akshaya Parthasarathy
doaj   +1 more source

Biomechanical and Displacement‐Related Considerations in the Design of a 3D‐Printed Composite Energy‐Storage‐and‐Return Prosthetic Foot

Advanced Materials Technologies, EarlyView.
For the first time, Continuous Fiber‐Reinforced 3D printing is used to fabricate a foot prosthesis, exploring the flexibility in the design space granted by additive manufacturing, evaluating computationally and experimentally the effect of different design features on the mechanical and biomechanical response of the material, to locally tune the ...
Jacopo Romanò, Lorenzo Garavaglia, Abdel Rahman Nedal Al Thahabi, Luca Michele Martulli, Gennaro Rollo, Andrea Sorrentino, Fabio Lazzari, Marino Lavorgna, Andrea Bernasconi, Emanuele Gruppioni, Simone Pittaccio   +10 more
wiley   +1 more source

High-Resolution, Adaptive Optics Imaging of the Human Trabecular Meshwork In Vivo

Translational Vision Science & Technology, 2019
Purpose To image the human trabecular meshwork (TM) in vivo using adaptive optics gonioscopy (AOG) with approximately 2-μm lateral resolution. Methods An existing Indiana University adaptive optics scanning laser ophthalmoscope was altered by adding a 12-
B. J. King, S. Burns, Kaitlyn A. Sapoznik, Ting Luo, T. Gast   +4 more
semanticscholar   +1 more source