Results 81 to 90 of about 9,645,786 (257)

Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor

, 2008
Trace amines are neurotransmitters whose role in regulating invertebrate physiology has been appreciated for many de-cades. Recent studies indicate that trace amines may also play a role in mammalian physiology by binding to a novel family of G protein ...
Robert J. Lefkowitz, Jonathan D. Violin, Salahpour, Ali, Tatyana D. Sotnikova, Sotnikova, Tatyana, Gainetdinov, Raul, Bernard Masri, Barak, Larry,, Violin, Jonathan, Zhang, Xiaodong, Larry S. Barak, Raul R. Gainetdinov, Ali Salahpour, Barak, Larry, S., Caron, Marc, Amy J. Ramsey, Marc G. Caron, Ramsey, Amy, Xiaodong Zhang, Masri, Bernard, Lefkowitz, Robert   +20 more
core   +1 more source

Culinary Chemistry as a Platform for Interfacial Materials Design

Advanced Materials Interfaces, EarlyView.
Culinary processes control interfaces through heating, shear, gelation, and molecular transport. This Review connects selected gastronomic examples with food‐derived nanomaterials, plasmonic sensing, anthocyanin photovoltaics, and intelligent packaging. Original agar‐based plasmonic films illustrate the proposed translation.
Josep Moreno, I. Brian Becerril‐Castro, Irene Calderon‐Gonzalez, Jaslyn Ru Ting Chen, Zhiming Wang, Alexander O. Govorov, José Manuel Romo‐Herrera, Neus Feliu, Wolfgang J. Parak, Miguel A. Correa‐Duarte, In Yee Phang, Xing Yi Ling, Ramón A. Alvarez‐Puebla   +12 more
wiley   +1 more source

Chitin‐Chitosan Cryogels for the Reversible Sequestration and Recovery of Heavy Metals From Wastewater

Advanced Materials Technologies, EarlyView.
Chitin‐chitosan cryogels with degrees of N‐acetylation from 12.2% to 71.4% are fabricated by dissolution, coagulation and lyophilization for the sequestration of heavy metals from water. Colorimetry and differential pulse voltammetry showed controlled adsorption and desorption capacities for As5+, Co2+ and Cu2+, making this material attractive for ...
Marta García‐Castrillo, Maialen Uribarrena, Jorge Sáiz, Guillermo Copello, Erlantz Lizundia   +4 more
wiley   +1 more source

The dopamine metabolite 3-methoxytyramine is a neuromodulator. [PDF]

PLoS ONE, 2010
Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, 3-methoxytyramine (3-MT), can induce ...
Tatyana D Sotnikova, Jean-Martin Beaulieu, Stefano Espinoza, Bernard Masri, Xiaodong Zhang, Ali Salahpour, Larry S Barak, Marc G Caron, Raul R Gainetdinov   +8 more
doaj   +1 more source

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists [PDF]

, 2015
Trace amine associated receptor 1 (TAAR1) is a G protein coupled receptor (GPCR) expressed in brain and periphery activated by a wide spectrum of agonists that include, but are not limited to, trace amines (TAs), amphetamine-like psychostimulants, and ...
Fossa P, Laurino A, Espinoza S, Rapposelli S, Chiellini G, Nesi G, Digiacomo M, Frascarelli S, Gainetdinov RR, Sabatini M, Macchia M, Cichero E, Zucchi R, Malvasi R, Raimondi L   +14 more
core   +2 more sources

Trace amine-associated receptor 1—Family archetype or iconoclast? [PDF]

Pharmacology & Therapeutics, 2007
Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the "trace amines" (TA) beta-phenylethylamine (PEA), tyramine (
openaire   +2 more sources

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

eLife, 2019
We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene, Taar1,
Alexandra M Stafford, Cheryl Reed, Harue Baba, Nicole AR Walter, John RK Mootz, Robert W Williams, Kim A Neve, Lev M Fedorov, Aaron J Janowsky, Tamara J Phillips   +9 more
doaj   +1 more source

Evidence for functional trace amine associated receptor-1 in normal and malignant B cells.

, 2011
Following the observation that dopaminergic components are present in normal and malignant B cells, we now provide evidence that they additionally express the functionally related trace amine-associated receptor-1 (TAAR1).
Gordon, John, Millan, MJ, Wasik, AM, Scanlan, T, Barnes, Nicholas; id_orcid   +4 more
core   +1 more source