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A chemoenzymatic synthesis of amide-containing quinazolin-4(<i>3H</i>)-one derivatives. [PDF]
RSC AdvMaphupha MM +3 more
europepmc +1 more source
Receptors of mammalian trace amines [PDF]
AAPS Journal, 2006 The discovery of a family of G-protein coupled receptors, some of which bind and are activated by biogenic trace amines, has prompted speculation as to the physiological role of these receptors. Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention ...
Anita H Lewin
exaly +3 more sources
Trace amine-associated receptors and their ligands [PDF]
British Journal of Pharmacology, 2006 Classical biogenic amines (adrenaline, noradrenaline, dopamine, serotonin and histamine) interact with specific families of G protein‐coupled receptors (GPCRs). The term ‘trace amines’ is used when referring top‐tyramine, β‐phenylethylamine, tryptamine and octopamine, compounds that are present in mammalian tissues at very low (nanomolar ...
David K. Grandy, T S Scanlan
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The vascular effects of trace amines and amphetamines
Pharmacology & Therapeutics, 2010Trace amines, including tyramine, beta-phenylethylamine (beta-PEA), tryptamine and octopamine, are biologically active amines mostly based on phenylethylamine, occurring in the body in trace amounts. They are a diverse group of naturally occurring and synthetic amines, which are also found in the diet and in herbal plants, such as ephedrine and ...
Kenneth J. Broadley
exaly +3 more sources
Trace amines and Tourette's syndrome
Neurochemical Research, 1993There has been considerable interest in recent years in possible neurochemical abnormalities in Tourette's Syndrome (TS). In studies combining neuropsychological and neurochemical measurements, we have investigated the possible roles of trace amines in this disorder.
G B, Baker +2 more
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Recognition of methamphetamine and other amines by trace amine receptor TAAR1
Nature, 2023Trace amine-associated receptor 1 (TAAR1), the founding member of a nine-member family of trace amine receptors, is responsible for recognizing a range of biogenic amines in the brain, including the endogenous β-phenylethylamine (β-PEA)1 as well as methamphetamine2, an abused substance that has posed a severe threat to human health and society3.
Heng Liu +16 more
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