Results 61 to 70 of about 67,614 (313)

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan   +22 more
wiley   +1 more source

EFEKTIVITAS FUNGSI PENDIDIKAN DAN REKAYASA LALULINTAS GUNA MENCEGAH KORBAN KECELAKAAN LALU LINTAS PADA ANAK-ANAK USIA SEKOLAH

open access: yesUnes Journal of Swara Justisia, 2019
On the Elucidation of Law No. 22 of 2009 on Traffic and Road Transport states Education and traffic engineering is the responsibility of the Police. Some victims from laka then are children of school age.
Adhi Jais, Ebit Bimas Saputra
doaj  

Simulation study on noise reduction of electric vehicle tire with built-in sound-absorbing material

open access: yesActa Acustica
Tire cavity noise is becoming more prominent as the speed of electric vehicles is getting higher. This study aims to use a built-in sound-absorbing material to reduce tire cavity noise.
Shi Tuo   +5 more
doaj   +1 more source

Review on Corrosion Mechanism and Mechanical Properties Degradation of Building Structural Steel [PDF]

open access: yesE3S Web of Conferences
Steel structure is favored by many designers because of its light weight, high strength, short construction period and good seismic performance, and is widely used in high-rise, super high-rise and long-span structures, but the shortcomings of steel ...
Zhang Yixin, Zhang Shumin, Liu Kai
doaj   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda   +12 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

open access: yesAdvanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley   +12 more
wiley   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

open access: yesAdvanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen   +30 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

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