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Trained Immunity Induced by Oxidized Low-Density Lipoprotein Is Dependent on Glutaminolysis. [PDF]
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Immunologic Research, 2021
The innate immune system acts rapidly in an identical and nonspecific way every time the body is exposed to pathogens. As such, it cannot build and maintain immunological memory to help prevent reinfection. Researchers contend that trained immunity is influenced by intracellular metabolic pathways and epigenetic remodeling.
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The innate immune system acts rapidly in an identical and nonspecific way every time the body is exposed to pathogens. As such, it cannot build and maintain immunological memory to help prevent reinfection. Researchers contend that trained immunity is influenced by intracellular metabolic pathways and epigenetic remodeling.
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“Training immunity” against nosocomial pathogens
Science Immunology, 2023Non-antigen vaccines that broadly activate innate immune responses reduce mortality against hospital-acquired bacterial and fungal pathogens.
Alexandra Schäfer, David R. Martinez
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Nature Reviews Immunology, 2020
New research suggests that haematopoietic stem cells (HSCs) can contribute to trained immunity. Stimulation with lipopolysaccharide establishes long-lasting epigenetic changes in HSCs that confer improved responsiveness to secondary stimulation.
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New research suggests that haematopoietic stem cells (HSCs) can contribute to trained immunity. Stimulation with lipopolysaccharide establishes long-lasting epigenetic changes in HSCs that confer improved responsiveness to secondary stimulation.
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Nature Reviews Immunology, 2018
Nanoparticles designed to prevent training of myeloid cells infiltrating allografts can promote long-term transplant acceptance and immunological tolerance.
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Nanoparticles designed to prevent training of myeloid cells infiltrating allografts can promote long-term transplant acceptance and immunological tolerance.
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Trained immunity in the mucosal diseases
WIREs Mechanisms of Disease, 2021AbstractImmune memory is well known as a signature of the adaptive immune system. Recently, enhanced responses to subsequent triggers are also observed in innate immune system, termed trained immunity (TI). Awakening of innate immune memory is required for host defense, such as anti‐pathogen and anti‐tumor responses.
Dou Yu, Jiaqi Zhang, Shuo Wang
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M. tuberculosis stifles trained immunity
Nature Reviews Microbiology, 2020A recent study found that Mycobacterium tuberculosis infection in mice reprogrammes haematopoietic stem cells, limiting myelopoiesis and impairing trained immunity.
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Marathon Training and Immune Function
Sports Medicine, 2007Many components of the immune system exhibit adverse change after marathon-type exertion. These immune changes occur in several compartments of the immune system and body (e.g. the skin, upper respiratory tract mucosal tissue, lung, peritoneal cavity, blood and muscle). Of all immune cells, natural killer (NK) cells, neutrophils and macrophages (of the
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