Results 61 to 70 of about 56,323 (331)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Specific multivalent molecules boost CRISPR-mediated transcriptional activation

Nature Communications
CRISPR/Cas-based transcriptional activators can be enhanced by intrinsically disordered regions (IDRs). However, the underlying mechanisms are still debatable.
Rui Chen, Xinyao Shi, Xiangrui Yao, Tong Gao, Guangyu Huang, Duo Ning, Zemin Cao, Youxin Xu, Weizheng Liang, Simon Zhongyuan Tian, Qionghua Zhu, Liang Fang, Meizhen Zheng, Yuhui Hu, Huanhuan Cui, Wei Chen   +15 more
doaj   +1 more source

The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila [PDF]

, 2013
BACKGROUND: The question of how cells re-establish gene expression states after cell division is still poorly understood. Genetic and molecular analyses have indicated that Trithorax group (TrxG) proteins are critical for the long-term maintenance of ...
Christian Beisel, Daniel Hess, Moritz Gerstung, Niko Beerenwinkel, Renato Paro, Tobias Kockmann, Tommy Schlumpf, Zhu Xhinzhou   +7 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants

Nature Communications
The Arabidopsis thaliana DREB2A transcription factor interacts with the negative regulator RCD1 and the ACID domain of subunit 25 of the transcriptional co-regulator mediator (Med25) to integrate stress signals for gene expression, with elusive molecular
Frederik Friis Theisen, Andreas Prestel, Steffie Elkjær, Yannick H. A. Leurs, Nicholas Morffy, Lucia C. Strader, Charlotte O’Shea, Kaare Teilum, Birthe B. Kragelund, Karen Skriver   +9 more
doaj   +1 more source

Introduction: Affective Histories of Queer and Trans Activism

SQS – Suomen Queer-tutkimuksen Seuran lehti, 2023
Non peer ...
Alasuutari, Varpu, Bootsmann, Merlin Sophie, Dynda, Barbara, Meier-Brix, Orlando, Zender, Ivo   +4 more
openaire   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes [PDF]

, 1994
The receptor for macrophage colony stimulating factor (CSF-1), the c- fms gene product, is a key determinant in the differentiation of monocytic phagocytes.
Barnett, C. J., Hume, D. A., Ostrowski, M. C., Reddy, M. A., Ross, I. L., Sweet, M. J., Yang, B. S., Yue, X.   +7 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Alternative splicing of activator CcbHLH1 gene accounts for anthocyanin absence in white cornflower

Ornamental Plant Research
Anthocyanins play crucial roles in conferring multicolored characteristics to higher plant organs. Previous studies have investigated the absence of anthocyanin accumulation in white cornflower petals, where the anthocyanin biosynthesis pathway was ...
Chengyan Deng, Xiaofan Zheng, Jiaying Wang, Yanfei Li, Jingjing Li, Min Lu, Ruina Gao, Chenyuan Ji, Qinghe Hao, Silan Dai   +9 more
doaj   +1 more source