Results 161 to 170 of about 6,162 (180)

Electronic absorption spectra of heterocyclic analogs of trans-chalcone

Chemistry of Heterocyclic Compounds, 1977
Thiophene, furan, and pyrrole analogs of trans-chalcone have UV spectra consisting of bands belonging to the spectra of the corresponding 2-acetylhetaryls and 2-hetarylideneacetones that are shifted bathochromically as a result of mutual perturbation of these two crossconjugated fragments.
M. Reinkhardt, A. A. Sukhorukov, A. Raushal', V. F. Lavrushin   +3 more
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Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase

Molecular Biology Reports, 2010
Trans-chalcone (1,3-diphenyl-2-propen-1-one), a biphenolic core structure of flavonoids precursor was tested for inhibitory activity toward alpha-amylase. Porcine pancreatic alpha-amylase was observed to be effectively inhibited by this compound, which showed competitive behavior with a K(i) of 48 μM. Soluble starch (the natural substrate of the enzyme)
Mahmoud, Najafian, Azadeh, Ebrahim-Habibi, Nastaran, Hezareh, Parichehreh, Yaghmaei, Kazem, Parivar, Bagher, Larijani   +5 more
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Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina

Experimental Eye Research, 2011
Retinal neovascularization (RNV) is a critical pathological event and a major cause of blindness. Vascular inflammation and oxidative stress have been shown to play a key role in the induction and progression of RNV. Trans-Chalcone-derived flavonoids have been previously shown to be negative modulators of oxidative stress and inflammatory responses as ...
Folami, Lamoke, Mohamed, Labazi, Annalisa, Montemari, Giovanni, Parisi, Monica, Varano, Manuela, Bartoli   +5 more
openaire   +2 more sources

Polycaprolactone/epoxide-functionalized silica composite microparticles for long-term controlled release of trans-chalcone

Journal of Polymer Engineering, 2022
Abstract In this study, controlled release of trans-chalcone was achieved by using a polycaprolactone-based hybrid system as the drug carrier material. Encapsulation efficiency was obtained in the range of 70–75% for various formulations and in vitro release studies, conducted at 37 °C and pH 7.4, revealed slow profile reaching 60 ...
Yasemin Kaptan, Yüksel Güvenilir
openaire   +1 more source

Chemical sensing of chalcones by voltammetry: trans-Chalcone, cardamonin and xanthohumol

Electrochimica Acta, 2013
Abstract Xanthohumol (XN) and cardamonin (CD) belong to the chemical class of chalcones which are phenolic compounds of large interest due to their health promoting properties. In the present work, their electrochemical behavior on a hanging mercury drop electrode (HMDE) is compared to trans -chalcone by means of cyclic voltammetry (CV).
Tavares, E.M., Carvalho, A.M., Gonçalves, Luis M., Valente, I.M., Moreira, M.M., Guido, L.F., Rodrigues, J.A., Doneux, Thomas, Barros, Aquiles   +8 more
openaire   +1 more source

Development of trans-Chalcone loaded pectin/casein biodegradable microcapsules: Efficacy improvement in the management of experimental colitis

International Journal of Pharmaceutics, 2023
Improved therapies for inflammatory bowel diseases are sorely needed. Novel therapeutic agents and the development of controlled release systems for targeted tissue delivery are interesting approaches to overcome these barriers. We investigated the activity of trans-chalcone (T) in acetic acid-induced colitis in mice and developed, characterized, and ...
Carla F.S. Guazelli, Victor Fattori, Barbara B. Colombo, Isabela S. Ludwig, Laisa G. Vicente, Renata M. Martinez, Sandra R. Georgetti, Alexandre Urbano, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri   +10 more
openaire   +2 more sources

Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing

The Journal of Supercritical Fluids, 2009
Abstract This work studies the possibility of enhancing the solubility of 1,3-diphenyl-2-propenone, the core structure of chalcones, through lipidic formulations under supercritical CO 2 processing. Microparticles of chalcone, alone and with lipid carriers, were produced by PGSS ® , a method which involves the quick depressurization of a gas ...
A.R. Sampaio de Sousa, Rodrigo Silva, Feng H. Tay, Ana Luísa Simplício, Sergei G. Kazarian, Catarina M.M. Duarte   +5 more
openaire   +1 more source

New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis

Acta Tropica, 2006
The present study was designed to investigate a new administration model and the antileishmanial activity of a semi-synthetic chalcone, benzylideneacetophenone (trans-chalcone). The antileishmanial activity of this product was first tested in vitro against promastigotes of L. braziliensis, L. tropica, L. infantum and L. amazonensis.
Jose, Piñero, Rosane M, Temporal, Antonio J, Silva-Gonçalves, I A, Jiménez, Isabel L, Bazzocchi, Alexis, Oliva, Antonio, Perera, Leonor L, Leon, Basilio, Valladares   +8 more
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trans-Chalcone modulates Leishmania amazonensis infection in vitro by Nrf2 overexpression affecting iron availability

European Journal of Pharmacology, 2019
Leishmania parasites infect macrophages causing a wide spectrum of human diseases encompassing from cutaneous to visceral forms. The drugs currently used in leishmaniasis treatment are highly toxic and associated with acquired resistance. Seeking novel therapeutic targets, we conducted a comprehensive in vitro study to investigate the action of trans ...
Milena Menegazzo, Miranda-Sapla, Fernanda, Tomiotto-Pellissier, João Paulo, Assolini, Amanda Cristina Machado, Carloto, Bruna Taciane da Silva, Bortoleti, Manoela Daiele, Gonçalves, Eliandro Reis, Tavares, Jean Henrique da Silva, Rodrigues, Andréa Name Colado, Simão, Lucy Megumi, Yamauchi, Celso Vataru, Nakamura, Waldiceu A, Verri, Idessania Nazareth, Costa, Ivete, Conchon-Costa, Wander Rogerio, Pavanelli   +14 more
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ChemInform Abstract: Chalcone Aziridines. Part 3. Reaction of trans‐Chalcone Aziridines with Isocyanates, Isothiocyanates and HSCN.

ChemInform, 1987
AbstractThe reaction of the aziridines (I) with the isocyanate (II) or with the isothiocyanates (VIII) yields the 1‐phenylcarbamoyl aziridines (III) or the thiazolines (IX).
F. G. WEBER, H. LIEPERT, H. + KOEPPEL
openaire   +1 more source