Results 11 to 20 of about 6,162 (180)

The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria. [PDF]

PLoS Neglected Tropical Diseases, 2019
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The search for a new chemotherapy against Babesia and Theileria parasites has become increasingly urgent due to the toxic side effects of and developed resistance
Gaber El-Saber Batiha, Amany Magdy Beshbishy, Dickson Stuart Tayebwa, Oluyomi Stephen Adeyemi, Hazem Shaheen, Naoaki Yokoyama, Ikuo Igarashi   +6 more
doaj   +6 more sources

The synthesis of chiral β-naphthyl-β-sulfanyl ketones via enantioselective sulfa-Michael reaction in the presence of a bifunctional cinchona/sulfonamide organocatalyst [PDF]

Beilstein Journal of Organic Chemistry, 2021
Cinchona alkaloid-derived organocatalysts are widely employed in various asymmetric transformations, yielding products with high enantiopurity. In this respect, a bifunctional quinine-derived sulfonamide organocatalyst was developed to catalyze the ...
Deniz Tözendemir, Cihangir Tanyeli
doaj   +2 more sources

The Solubility and Stability of Heterocyclic Chalcones Compared to Trans-chalcone [PDF]

Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2020
Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thio­
Cremeens, Matthew E, D'Ambruoso, Gemma D, Hall, Charlie, Hall, Simon R, Matsumoto, Masaomi, Potticary, Jason, Pridmore, Natalie E, Sweeting, Stephen, Warren, Stephen D   +8 more
core   +6 more sources

Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone [PDF]

MethodsX
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho, A. Caeiro, H.C. Sousa, M.E.M. Braga, M.G. Campos   +4 more
doaj   +2 more sources

Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice [PDF]

Archives of Endocrinology and Metabolism, 2015
Objective Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity.Materials and methods NMRI male mice (n = 48) were ...
Fatemeh Jalalvand, Mahsa M. Amoli, Parichehreh Yaghmaei, Masoud Kimiagar, Azadeh Ebrahim-Habibi   +4 more
doaj   +4 more sources

Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone [PDF]

Chemical Communications, 2015
Sortase A (SrtA) from Gram positive pathogens is an attractive target for inhibitors due to its role in the attachment of surface proteins to the cell wall.
Amarnath Maitra, Bryan Hanley, Chenna, Clancy, David J. Clarke, Daynea J. Wallock-Richards, Dominic J. Campopiano, Exterkate, Frankel, Hu, Hu, Igarashi, Ilangovan, Jon Marles-Wright, Kang, Kim, Lemos, Maresso, Maresso, Marraffini, Michael Dodds, Oh, Park, Race, Schneewind, Schneewind, Scott, Spirig, Ton-That, Ton-That, Ton-That, Ton-That, Veitch, Zhang, Zong   +34 more
core   +6 more sources

Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats [PDF]

Endocrine Regulations, 2018
Objective. Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive effects, especially on miR-451 as an inflammatory regulator, is poorly understood. In this regard, this microRNA (miRNA)
Karimi-Sales Elham, Jeddi Sajad, Ghaffari-Nasab Arshad, Salimi Mina, Alipour Mohammad Reza   +4 more
doaj   +3 more sources

trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023
Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders.
Elham Karimi-Sales, Mohammad Reza Alipour   +1 more
doaj   +1 more source

Protective Effects of Trans-Chalcone on Myocardial Ischemia and Reperfusion Challenge through Targeting Phosphoinositide 3-kinase/Akt-inflammosome Interaction

Journal of Physiological Investigation
Ischemia-reperfusion (IR) injury remains a pivotal contributor to myocardial damage following acute coronary events and revascularization procedures. Phosphoinositide 3-kinase (PI3K), a key mediator of cell survival signaling, plays a central role in ...
Jing Wang, Shaik Althaf Hussain, Narendra Maddu, Haijun Li   +3 more
doaj   +3 more sources

Exploring the Therapeutic Potential of trans-Chalcone: Modulation of MicroRNAs Linked to Breast Cancer Progression in MCF-7 Cells. [PDF]

Int J Mol Sci, 2023
Breast cancer is responsible for 25% of all cancers that affect women. Due to its high heterogeneity pattern in clinical diagnosis and its molecular profile differences, researchers have been seeking new targets and therapies, with more specificity and fewer side effects.
Komoto TT, Nishimura FG, Evangelista AF, de Freitas AJA, da Silva G, Silva WA, Silva WA, Peronni K, Marques MMC, Marins M, Fachin AL.   +10 more
europepmc   +3 more sources