Acarbose versus trans-chalcone: comparing the effect of two glycosidase inhibitors on obese mice [PDF]
Archives of Endocrinology and Metabolism, 2015 Objective Acarbose and trans-chalcone are glucosidase inhibitors whose beneficial effects have been demonstrated in diabetes. The present study aimed at investigating their potential effects in obesity.Materials and methods NMRI male mice (n = 48) were ...
Fatemeh Jalalvand +4 more
doaj +6 more sources
In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma [PDF]
BMC Cancer, 2023 Background Angiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its receptor 2 (VEGFR-2).
Anna Senrung +9 more
doaj +4 more sources
Effect of trans-chalcone on hepatic IL-8 through the regulation of miR-451 in male rats [PDF]
Endocrine Regulations, 2018 Objective. Trans-chalcone is a chalcone with hepatoprotective and anti-inflammatory effects. However, the mechanism of these positive effects, especially on miR-451 as an inflammatory regulator, is poorly understood. In this regard, this microRNA (miRNA)
Karimi-Sales Elham +4 more
doaj +4 more sources
The effects of trans-chalcone and chalcone 4 hydrate on the growth of Babesia and Theileria. [PDF]
PLoS Neglected Tropical Diseases, 2019 BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The search for a new chemotherapy against Babesia and Theileria parasites has become increasingly urgent due to the toxic side effects of and developed resistance
Gaber El-Saber Batiha +6 more
doaj +5 more sources
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone [PDF]
Chemical Communications, 2015 Sortase A (SrtA) from Gram positive pathogens is an attractive target for inhibitors due to its role in the attachment of surface proteins to the cell wall.
Daynea J. Wallock-Richards +6 more
core +8 more sources
Exploring the Therapeutic Potential of trans-Chalcone: Modulation of MicroRNAs Linked to Breast Cancer Progression in MCF-7 Cells. [PDF]
Int J Mol Sci, 2023 Breast cancer is responsible for 25% of all cancers that affect women. Due to its high heterogeneity pattern in clinical diagnosis and its molecular profile differences, researchers have been seeking new targets and therapies, with more specificity and fewer side effects.
Komoto TT +10 more
europepmc +5 more sources
Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review. [PDF]
Future Med ChemAim: Trans-chalcone has emerged as a promising candidate for new therapeutic alternatives, owing to its pharmacological properties and potential in various medical areas. This study aimed to conduct a systematic review of articles, patents and clinical trials on trans-chalcone's applications and biological activities.Areas covered: The review proposed ...
Santos AM +7 more
europepmc +5 more sources
Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine [PDF]
BMC Proc, 2014 Background Dermatophytes are adapted to grow in keratinized tissues such as skin, nail and hair. Trichophyton rubrum is the most frequent cause of dermatophytosis in Brazil and in the world [1]. Despite its incidence there are only a limited number of antifungal drugs available for clinical use and some drugs are highly toxic to humans. In this regard,
Komoto T +5 more
europepmc +4 more sources
The solubility and stability of heterocyclic chalcones compared with trans-chalcone [PDF]
Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, 2019 Heterocyclic chalcones are a recently explored subgroup of chalcones that have sparked interest due to their significant antibacterial and antifungal capabilities. Herein, the structure and solubility of two such compounds, (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one and (E)-3-phenyl-1-(1H-pyrrol-2-yl)prop-2-en-1-one, are assessed.
Stephen G. Sweeting +8 more
core +9 more sources
Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction. [PDF]
Genes CancerIn some breast cancers, altered estrogen-sulfotransferase (SULT1E1) and its inactivation by oxidative-stress modifies E2 levels. Parallelly, hypoxia-inducible tissue-damaging factors (HIF1α) are induced. The proteins/genes expressions of these factors were verified in human-breast-cancer tissues.
Nazmeen A, Maiti S, Maiti S.
europepmc +5 more sources