Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine [PDF]
BMC Proc, 2014 Background Dermatophytes are adapted to grow in keratinized tissues such as skin, nail and hair. Trichophyton rubrum is the most frequent cause of dermatophytosis in Brazil and in the world [1]. Despite its incidence there are only a limited number of antifungal drugs available for clinical use and some drugs are highly toxic to humans. In this regard,
Komoto T +5 more
europepmc +3 more sources
Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review. [PDF]
Future Med ChemAim: Trans-chalcone has emerged as a promising candidate for new therapeutic alternatives, owing to its pharmacological properties and potential in various medical areas. This study aimed to conduct a systematic review of articles, patents and clinical trials on trans-chalcone's applications and biological activities.Areas covered: The review proposed ...
Santos AM +7 more
europepmc +3 more sources
Combined Analysis of Transcriptome and Metabolome Explains the Differences in Pulp Color in Jackfruit. [PDF]
Plant DirectABSTRACT The pulp color of jackfruit reflects variations in its nutritional composition and influences market preference. We investigated the mechanism underlying pulp coloration through an integrated transcriptomic and metabolomic analysis of three jackfruit cultivars—light yellow “THA”, yellow “GTM”, and orange “YNH”.
Liang J +8 more
europepmc +2 more sources
pH-Induced Orthogonal Photoresponse of trans-Chalcone Isomers and Related Compounds in Equilibria
Colorants, 2023 Photoresponsive molecular devices can be a valuable tool to promote chemical changes in response to multiple signals, such as photons and pH, to deliver drugs or to detect physiological conditions in vivo.
Jeonghee Kang +3 more
doaj +1 more source
Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction. [PDF]
Genes CancerIn some breast cancers, altered estrogen-sulfotransferase (SULT1E1) and its inactivation by oxidative-stress modifies E2 levels. Parallelly, hypoxia-inducible tissue-damaging factors (HIF1α) are induced. The proteins/genes expressions of these factors were verified in human-breast-cancer tissues.
Nazmeen A, Maiti S, Maiti S.
europepmc +3 more sources
Chalcone-based Selective Inhibitors of a C4 Plant Key Enzyme as Novel Potential Herbicides [PDF]
, 2016 Weeds are a challenge for global food production due to their rapidly evolving resistance against herbicides. We have identified chalcones as selective inhibitors of phosphoenolpyruvate carboxylase (PEPC), a key enzyme for carbon fixation and biomass ...
Bott, M. +7 more
core +2 more sources
Polymer processing using supercritical fluid based technologies for drug delivery and tissue engineering applications [PDF]
, 2015 From the use of botanical plants in early human civilizations through synthetic chemistry and biotechnology, drug research has always passionate scientists creating exciting challenges to a large number of researchers from different fields, thus ...
Duarte, Ana Rita C. +2 more
core +1 more source
A Photoswitchable Chalcone-Carbohydrate Conjugate Obtained by CuAAC Click Reaction [PDF]
, 2022 Publisher Copyright: © 2022 by the authors.Flavylium/Chalcone-based molecular switches comprise features such as pH-gated photochromism and fluorescence properties that make them attractive for many applications, ranging from stimuli-responsive materials
Basílio, Nuno +2 more
core +1 more source
Cyclodienyl 1,3 - Dianionic Synthons: A Novel Synthesis of 5,5 - Dimethyl - 1,3 - Bis - (trimethylsilyl) Cyclohexa - 1,3 - Diene and its Diels - Alder [π4s+π2s] Cycloadditions with Six Dienophiles [PDF]
, 2012 The synthesis of 5,5-dimethyl-1,3-bis(trimethylsilyl)cyclohexa-1,3-diene: a novel cyclic 1,3-dianionic synthon is reported by the Wurtz-Fittig coupling reaction of 1,3-dichloro-5,5-dimethylcyclohexa-1,3-diene with metallic sodium and ...
Hariprasad Suresh, . +1 more
core +1 more source
Orbital: The Electronic Journal of Chemistry, 2021 This paper presents the conformational analysis of three chalcone compounds, 1'-nitro-4-hydroxy-3-metoxychalcoea (o-CHAL), 2'-nitro-4-hydroxy-3-metoxychalcone (m-CHAL) and 3'-nitro-4-hydroxiy3-metoxychalcone (p-CHAL).
Hualace Vinicius Emiliano +3 more
doaj +3 more sources