Results 21 to 30 of about 675,014 (180)
Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction. [PDF]
Genes CancerBackground: In some breast cancers, altered estrogen-sulfotransferase (SULT1E1) and its inactivation by oxidative-stress modifies E2 levels. Parallelly, hypoxia-inducible tissue-damaging factors (HIF1α) are induced.
Nazmeen A, Maiti S, Maiti S.
europepmc +4 more sources
Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine [PDF]
BMC Proc, 2014 Background Dermatophytes are adapted to grow in keratinized tissues such as skin, nail and hair. Trichophyton rubrum is the most frequent cause of dermatophytosis in Brazil and in the world [1]. Despite its incidence there are only a limited number of antifungal drugs available for clinical use and some drugs are highly toxic to humans. In this regard,
Komoto T +5 more
europepmc +5 more sources
Journal of Physiological InvestigationIschemia-reperfusion (IR) injury remains a pivotal contributor to myocardial damage following acute coronary events and revascularization procedures. Phosphoinositide 3-kinase (PI3K), a key mediator of cell survival signaling, plays a central role in ...
Jing Wang +3 more
doaj +3 more sources
Chemical Communications, 2015 Sortase A (SrtA) from Gram positive pathogens is an attractive target for inhibitors due to its role in the attachment of surface proteins to the cell wall.
Daynea Wallock-Richards +6 more
semanticscholar +8 more sources
Biomedicine & Pharmacotherapy, 2019 Non-alcoholic steatohepatitis (NASH) is an inflammatory and progressive form of non-alcoholic fatty liver disease. However, there are no FDA-approved drugs for this condition. Lipids accumulated in NASH have a direct role in the progression of this disease.
Elham Karimi-Sales +2 more
semanticscholar +5 more sources
Electron Paramagnetic Resonance Study of the Radiation Damage in Trans-Chalcone Single Crystal
Acta Physica Polonica A, 2019 Gamma irradiated trans-chalcone (C15H12O) single crystals are investigated at 120 K using electron paramagnetic resonance technique. Trans-chalcone single crystals are irradiated with Co-γ rays, at room temperature.
B. Çalişkan, A. C. Çalişkan
semanticscholar +7 more sources
Semina: Ciências Biológicas e da Saúde, 2023 Trans-chalcone (TC) is a flavonoid precursor characterized by a wide spectrum of action, with anti-inflammatory and antioxidant effects. However, no validated methods are available in official compendia for the analysis of this substance.
Renata M. Martinez +6 more
semanticscholar +3 more sources
Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone [PDF]
MethodsXIn this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone content ...
J.R.S. Botelho +4 more
doaj +2 more sources
The natural compound trans‐chalcone induces programmed cell death in Arabidopsis thaliana roots [PDF]
Plant, Cell & Environment, 2012 ABSTRACTChalcone (1,3‐diphenyl‐2‐propen‐1‐one) is an aromatic ketone precursor of important molecules in plants such as flavonoids or anthocyanins. Its phytotoxicity has been demonstrated on different plant species, but to date little is known about the mechanisms of action of this secondary metabolite at plant cellular level.
Carla Díaz‐Tielas +4 more
openalex +4 more sources
Journal of food biochemistry, 2020 High-fat diet (HFD) intake is linked to chronic kidney disease. Farnesoid X receptor (FXR) controls the renal lipid metabolism and fibrosis. The purpose of the current study was to evaluate the possible impacts of trans-chalcone on HFD-induced changes in
M. Alipour, S. Jeddi, Elham Karimi-Sales
semanticscholar +2 more sources