Measuring and Interpreting Holo-Transcobalamin (Holo-Transcobalamin II) [PDF]
Clinical Chemistry, 2002 At one time, diagnosing cobalamin deficiency was fairly simple, usually involving a patient with clinical problems, and was usually settled by determining whether the serum cobalamin concentration was low or not. As reviewed elsewhere (1), things began to change after sensitive metabolic tests were introduced and as attention extended to the cobalamin ...
Ralph Carmel
openaire +2 more sources
Hypervitaminemia B12 in the elderly: a forgotten marker of serious underlying diseases [PDF]
European Journal of Case Reports in Internal MedicineHypervitaminemia B12, long neglected in clinical practice, is a biological anomaly whose pathological significance remains largely underestimated, particularly in the elderly.
Abrar-Ahmad Zulfiqar
doaj +2 more sources
Transport function of transcobalamin II [PDF]
Journal of Clinical Investigation, 1972 The uptake of free and bound (57)CoB(12), principally to transcobalamin II (TC II), was studied in isolated, perfused liver and kidney of the dog. (1) There was good uptake of canine TC II-B(12) by both organs. (2) In the liver TC II enhanced uptake over that of free B-12. (3) Renal uptake of free B-12 was greater than that of TC II-B(12).
M E, Rappazzo, C A, Hall
openaire +3 more sources
Measurement of Transcobalamin by ELISA [PDF]
Clinical Chemistry, 2000 AbstractBackground: Transcobalamin is essential for the cellular internalization of cobalamin. Methods to quantify the unsaturated protein are available, but few attempts have been made to develop methods to quantify the sum of unsaturated and cobalamin saturated transcobalamin.Methods: γ-Globulins from two polyclonal rabbit antibodies against ...
Nexø, Ebba +3 more
openaire +5 more sources
Direct Assay for Cobalamin Bound to Transcobalamin (Holo-Transcobalamin) in Serum [PDF]
Clinical Chemistry, 2002 Abstract Background: Only cobalamin carried by transcobalamin (holo-transcobalamin) is available for cellular uptake and hence is physiologically relevant. However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a novel holo-transcobalamin assay based on solid-phase capture of transcobalamin.
Ulleland, M. +6 more
openaire +4 more sources
Transcobalamin II Deficiency in an Infant with a Novel Mutation. [PDF]
Turk Arch Pediatr, 2022 Toret E, Özdemir ZC, Bor Ö.
europepmc +2 more sources
Transcobalamin deficiency: vitamin B12 deficiency with normal serum B12 levels. [PDF]
BMJ Case Rep, 2019 Khera S, Pramanik SK, Patnaik SK.
europepmc +3 more sources
Long-term outcome of a patient with Transcobalamin deficiency caused by the homozygous c.1115_1116delCA mutation in TCN2 gene: a case report. [PDF]
Ital J Pediatr, 2021 Martino F +6 more
europepmc +3 more sources
Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors. [PDF]
Med Sci Monit, 2020 Zhu X +6 more
europepmc +2 more sources