Results 11 to 20 of about 1,943 (192)
Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins' Synthesis in Solid Cancers. [PDF]
Nutrients, 2022 Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation, purine synthesis, succinylation and ATP production. Ensuring these functions in
Lacombe V, Lenaers G, Urbanski G.
europepmc +2 more sources
Quantitative separation of serum transcobalamins on charged cellulose filters [PDF]
FEBS Letters, 1974 Jacob Selhub +3 more
openalex +2 more sources
Vitamin B12 Pharmaconutrition for COVID-19
Revista de Nutrición Clínica y Metabolismo, 2020 Mortality from COVID-19 disease is much greater in the elderly, many of whom succumb to acute respiratory distress syndrome (ARDS) triggered by the viral infection.
William Manzanares, Gil Hardy
doaj +1 more source
Mouse Transcobalamin Has Features Resembling both Human Transcobalamin and Haptocorrin [PDF]
PLoS ONE, 2011 In humans, the cobalamin (Cbl) -binding protein transcobalamin (TC) transports Cbl from the intestine and into all the cells of the body, whereas the glycoprotein haptocorrin (HC), which is present in both blood and exocrine secretions, is able to bind also corrinoids other than Cbl. The aim of this study is to explore the expression of the Cbl-binding
Hygum, Katrine +7 more
openaire +5 more sources
Association between oral cleft and transcobalamin 2 polymorphism in a sample study from Nassiriya, Iraq. [PDF]
Int J Immunopathol Pharmacol, 2019 Carinci F +8 more
europepmc +3 more sources
Aggregation of Transcobalamin II
Experimental Biology and Medicine, 1972 SummaryPurification of transcobalamin II prepared from normal serum by DEAE-cellulose column chromatography and polyacryalmide gel electrophoresis resulted in aggregation of this vitamin B12 binder. Exposure of transcobalamin II to 8 M urea resulted in liberation of the vitamin and aggregation of the binder.
L M, Meyer, E J, Gizis, C, Calas
openaire +2 more sources
Transcobalamin II deficiency at birth
Molecular Genetics and Metabolism, 2009 Transcobalamin II deficiency (# MIM 275350) is a rare, recessively inherited disorder of cobalamin transport that leads to intracellular cobalamin depletion with secondary impairment of methionine synthetase and methyl-malonyl CoA mutase activities.
Ratschmann, Rene +8 more
openaire +5 more sources
São Paulo Medical JournalCONTEXT AND OBJECTIVE: There is evidence that polymorphisms of genes involved in folate metabolism may be associated with higher risk that mothers may bear a Down's syndrome (DS) child.
Joice Matos Biselli +5 more
doaj +1 more source
Transcobalamin (TC) deficiency and newborn screening [PDF]
Journal of Inherited Metabolic Disease, 2011 Dear Editor, We would like to update the readership about transcobalamin (TC) deficiency and newborn screening. In a recent article we described two siblings with TC deficiency (Prasad et al. 2008). The older child was clinically symptomatic with pancytopenia and his sister was diagnosed at birth by mutation analysis.
Prasad, Chitra +3 more
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Discordant Vitamin B12 Results in an IgA Nephropathy Patient
Journal of Clinical Laboratory Analysis, EarlyView.ABSTRACT Background Discordant Vitamin B12 results can result from immunoassay interferences, potentially leading to unnecessary diagnostic procedures and misdiagnoses if not properly recognized. Case Presentation A 76‐year‐old male with a history of IgA nephropathy, hypertension, and other comorbidities presented with unexpectedly elevated total ...
Oytun Portakal +3 more
wiley +1 more source