Results 121 to 130 of about 5,189,368 (329)
Frontiers in Genetics, 2015 DNA replication and transcription are vital cellular processes during which the genetic information is copied into complementary DNA and RNA molecules.
Alessandra eBrambati +5 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Frontiers in Molecular Biosciences, 2016 DNA-dependent multisubunit RNA polymerase (RNAP) is the key enzyme of gene expression and a target of regulation in all kingdoms of life. It is a complex multifunctional molecular machine which, unlike other DNA-binding proteins, engages in extensive and
Sergei Borukhov, Jookyung Lee
doaj +1 more source
The Interplay between G-quadruplex and Transcription
Current Medicinal Chemistry, 2019 : G4 DNA is a non-canonical DNA structure consisting of a stacked array of G-quartets held together by base pairing between guanine bases. The formation of G4 DNA requires a cluster of guanine-runs within a strand of DNA.
Nayun Kim
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits. [PDF]
, 2019 The cardiac transcription factor (TF) gene NKX2-5 has been associated with electrocardiographic (EKG) traits through genome-wide association studies (GWASs), but the extent to which differential binding of NKX2-5 at common regulatory variants contributes
Benaglio, Paola +17 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Nature Communications, 2017 Covariance of gene expression pairs is due to a combination of shared genetic and environmental factors. Here the authors estimate the genetic correlation between highly heritable pairs and identify transcription factor control and chromatin interactions
Samuel W. Lukowski +17 more
doaj +1 more source
Roles of transposable elements in the regulation of mammalian transcription
Nature reviews. Molecular cell biology, 2022 Raquel Fueyo +3 more
semanticscholar +1 more source
Survey of variation in human transcription factors reveals prevalent DNA binding changes
Science, 2016 Variation and transcription factor binding Little is known about the phenotypic and functional effects of genetic variants that result in amino acid changes within functional proteins. Barrera et al.
Luis A. Barrera +21 more
semanticscholar +1 more source