Results 131 to 140 of about 5,008,846 (367)
Most Probable Evolution Trajectories in a Genetic Regulatory System Excited by Stable Lévy Noise [PDF]
arXiv, 2018 We study the most probable trajectories of the concentration evolution for the transcription factor activator in a genetic regulation system, with non-Gaussian stable L\'evy noise in the synthesis reaction rate taking into account. We calculate the most probable trajectory by spatially maximizing the probability density of the system path, i.e., the ...
arxiv
Genetic Variation in Transcription Factor Binding Sites
International Journal of Molecular Sciences, 2023 The interaction between transcription factors (TFs) and DNA is the core process that determines the state of a cell’s transcriptome [...]
openaire +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Transcriptional control of stem cell fate by E2Fs and Pocket Proteins
Frontiers in Genetics, 2015 E2F transcription factors and their regulatory partners, the pocket proteins (PPs), have emerged as essential regulators of stem cell fate control in a number of lineages.
Lisa Marie Julian +2 more
doaj +1 more source
The evolution of complex gene regulation by low specificity binding sites
, 2012 Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B. +1 more
core +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
The Genetic Code Kit: An Open-Source Cell-Free Platform for Biochemical and Biotechnology Education
Frontiers in Bioengineering and Biotechnology, 2020 Teaching the processes of transcription and translation is challenging due to the intangibility of these concepts and a lack of instructional, laboratory-based, active learning modules.
Layne C. Williams +13 more
doaj +1 more source
The style of genetic computing [PDF]
arXiv, 2003 Cells receive a wide variety of cellular and environmental signals, which must be processed combinatorially to generate specific and timely genetic responses. We present here a theoretical study on the combinatorial control and integration of transcription signals, with the finding that cis-regulatory systems with specific protein-DNA interaction and ...
arxiv
Bayesian estimation of Differential Transcript Usage from RNA-seq data [PDF]
, 2017 Next generation sequencing allows the identification of genes consisting of differentially expressed transcripts, a term which usually refers to changes in the overall expression level. A specific type of differential expression is differential transcript usage (DTU) and targets changes in the relative within gene expression of a transcript.
arxiv +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source