Results 151 to 160 of about 4,501,017 (312)

Unlocking oncoembryonic programs for clinical advances in cancer therapy. [PDF]

Clin Transl Med
Dalessi T, Fazilaty H.
europepmc   +1 more source

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Transcription of the Genetic Material

The American Biology Teacher, 1971
openaire   +2 more sources

Co-Occurrence of Endometriosis with Systemic Lupus Erythematosus: Genetic Aspects. [PDF]

Int J Mol Sci
Zervou MI, Tarlatzi TB, Grimbizis GF, Niewold TB, Tarlatzis BC, Bertsias G, Goulielmos GN.   +6 more
europepmc   +1 more source

Transcription Factor–Mediated Differentiation of Human iPSCs into Neurons

Current Protocols in Cell Biology, 2018
Michael S. Fernandopulle, Ryan Prestil, C. Grunseich, Chao Wang, L. Gan, Michael E. Ward   +5 more
semanticscholar   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Deciphering the etiology of congenital scoliosis: A genetic and epigenetic perspective. [PDF]

World J Orthop
Zhao R, Zhao JR, Xue X, Ma D.
europepmc   +1 more source

Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin

Clinical pharmacology and therapy, 2014
Srijib Goswami, S. Yee, S. Stocker, J. Mosley, M. Kubo, R. Castro, J. Mefford, Wen Cc, Xiaomin Liang, J. Witte, C. Brett, S. Maeda, M. D. Simpson, M. Hedderson, R. Davis, D. Roden, K. Giacomini, R. Savic   +17 more
semanticscholar   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML. [PDF]

J Transl Med
Li XP, Gao Y, Zhao BT, Dai YT, Mao JY, Liang Y, Jiang L.   +6 more
europepmc   +1 more source