Results 161 to 170 of about 4,501,017 (312)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

The Primary Role of Noncoding RNA in the Pathogenesis of Cancer. [PDF]

Genes (Basel)
Shah A.
europepmc   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Genetic neurocognitive profile of autism unveiled with gene transcription

Neurobiology of Disease
How neurocognitive processes elaborate phenotypic heterogeneity within autism spectrum disorder (ASD) remains unknown. Applying the principal component analysis to the Neurosynth database, we established neurocognitive profiles to characterize the ...
Yingxing Zhang, Fangfang Li, Hongli Wu, Wei Du, Jianhua Shu, Anqing Wang, Chunsheng Xu, Chuanfu Li, Ya Wang, Sheng Hu   +9 more
doaj  

Development of the coronavirus reverse genetic system: Core technology for pathogenesis mechanisms research and vaccine/drug development. [PDF]

Virulence
Zhang Y, Hou R, Wei Z, Yuan J, Zu S.
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Highly Conserved Genetic Factors Regulating <i>bla</i>_NDM Gene Expression. [PDF]

J Microbiol Biotechnol
Xu J, Zhu J, Mei C, Liu X, Gong Z, Huang J, Chai H.   +6 more
europepmc   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Case Report: The nonsense variation of the cardiac transcription factor <i>NKX2-5</i> has been identified in a Chinese family with nonsyndromic congenital heart disease. [PDF]

Front Genet
Zhang H, Chen J, Wang H, Xiang Q, Liu S.
europepmc   +1 more source

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

Nature, 2011
C. Colantuoni, B. Lipska, Tianzhang Ye, T. Hyde, R. Tao, J. Leek, E. Colantuoni, A. Elkahloun, M. Herman, D. Weinberger, J. Kleinman   +10 more
semanticscholar   +1 more source