Results 161 to 170 of about 1,570,740 (185)
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Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966
The purine and pyrimidine base sequence of DNA , permanent repository of the genetic information, must be transcribed on to ribopolynucleotides before genotype can be translated into phenotype. This transcription gives rise to three recognizably different classes of RNA molecules: (1) two ...
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The purine and pyrimidine base sequence of DNA , permanent repository of the genetic information, must be transcribed on to ribopolynucleotides before genotype can be translated into phenotype. This transcription gives rise to three recognizably different classes of RNA molecules: (1) two ...
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Tissue Specificity of Genetic Transcription
1972The basic biochemical differences which exist between cells in animal tissues are reflections of characteristic patterns of proteins. The process (es) of differentiation, therefore, may be described as the process (es) whereby cells, presumably of identical genotype, develop into phenotypically distinct entities which reflect characteristic patterns of
R B, Church, I R, Brown
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Genetic Determinants of 5–Lipoxygenase Transcription
International Archives of Allergy and Immunology, 1999<b>Background: </b>5 Lipoxygenase (5–LO) is a critical enzyme in the production of the leukotrienes. We have identified a series of mutations in the 5–LO gene that modify gene transcription. These mutations consist of addition of an Sp–1 binding motif (–GGGCGG–) or deletion of one or two Sp–1 binding motifs in the 5–LO core promoter.
J M, Drazen, E S, Silverman
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Diversity of Regulation of Genetic Transcription
Nature New Biology, 1972Functional coupling of the translational machinery to transcription is obligatory for the transcription of some genes, including the trp operon, but not for others.
F, Imamoto, S, Tani
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Collinearity of Transcriptional and Traditional Genetic Maps
Nature New Biology, 1972THE transcriptional mapping method1 makes possible the detection of polycistronic operons in systems which are not amenable to fine structure genetic mapping. The theory behind transcriptional mapping is that a defined interference with the travel of the genetic transcribing enzyme can be used for genetic analysis in a variety of ways.
K S, Webb, M A, Bleyman
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Ionizing Radiation: Effect on Genetic Transcription
Science, 1964Cells of Escherichia coli grown on maltose can be induced by the addition of thiomethyl galactoside to produce β-galactosidase. If cells are irradiated shortly after induction, the transcription of the DNA ceases, and the enzyme produced by the messenger RNA is observed to reach a maximum.
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Nucleosomes and transcription: recent lessons from genetics
Current Opinion in Genetics & Development, 1997Substantial evidence exists that nucleosomes affect transcription and that additional factors modify nucleosome function. Recent work has demonstrated that different types of histone mutants can be classified by their distinct effects on transcription in vivo.
G A, Hartzog, F, Winston
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Transcription control reprogramming in genetic backup circuits
Nature Genetics, 2005A key question in molecular genetics is why severe mutations often do not result in a detectably abnormal phenotype. This robustness was partially ascribed to redundant paralogs that may provide backup for one another in case of mutation. Mining mutant viability and mRNA expression data in Saccharomyces cerevisiae, we found that backup was provided ...
Kafri, R., Bar-Even, A., Pilpel, Y.
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Genetic and Epigenetic Control of RKIP Transcription
Critical Reviews in Oncogenesis, 2014Raf kinase inhibitory protein (RKIP) is known to modulate key signaling cascades and regulate normal physiological processes such as cellular proliferation, differentiation, and apoptosis. The expression of RKIP is found to be downregulated in several cancer metastases and the repressed RKIP expression can be reactivated on treatment with ...
Ila, Datar +6 more
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Transcription factories: genetic programming in three dimensions
Current Opinion in Genetics & Development, 2012Among the most intensively studied systems in molecular biology is the eukaryotic transcriptional apparatus, which expresses genes in a regulated manner across hundreds of different cell types. Several studies over the past few years have added weight to the concept that transcription takes place within discrete 'transcription factories' assembled ...
Lucas Brandon, Edelman, Peter, Fraser
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