Results 181 to 190 of about 5,189,368 (329)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Special Issue "Genetic Regulation of Plant Growth and Protection". [PDF]

Int J Mol Sci
Li J, Tong X, Li Z, Hou Y.
europepmc   +1 more source

Transcription Factor–Mediated Differentiation of Human iPSCs into Neurons

Current Protocols in Cell Biology, 2018
Michael S. Fernandopulle, Ryan Prestil, C. Grunseich, Chao Wang, L. Gan, Michael E. Ward   +5 more
semanticscholar   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes. [PDF]

Int J Mol Sci
Moya-Valera C, Arita AF, Lara-Hernández F, García-García AB, Chaves FJ.   +4 more
europepmc   +1 more source

Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin

Clinical pharmacology and therapy, 2014
Srijib Goswami, S. Yee, S. Stocker, J. Mosley, M. Kubo, R. Castro, J. Mefford, Wen Cc, Xiaomin Liang, J. Witte, C. Brett, S. Maeda, M. D. Simpson, M. Hedderson, R. Davis, D. Roden, K. Giacomini, R. Savic   +17 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

High-density genetic map construction using whole-genome resequencing of the <i>Cymbidium eburneum</i>('Duzhan Chun') × <i>Cymbidium insigne</i> ('Meihua Lan') F1 population and localization of flower color genes. [PDF]

Front Plant Sci
Han Y, Cui Y, Chen Y, Rao D, Wu E, Gan R, Li T, Tian M.   +7 more
europepmc   +1 more source