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Genetics in Light of Transcriptional Adaptation
Trends in Genetics, 2020Genetics has recently benefited from the genome engineering revolution: genes can be knocked out, knocked down, or activated more easily than ever before. This range of genetic manipulations has also provided a range of outcomes, sometimes contradictory. But how much interesting biology hides within these discrepancies?
Didier Y.R. Stainier +2 more
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Diversity of Regulation of Genetic Transcription [PDF]
Nature New Biology, 1972 Functional coupling of the translational machinery to transcription is obligatory for the transcription of some genes, including the trp operon, but not for others.
S. Tani +3 more
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Advances in AP2/ERF super-family transcription factors in plant
Critical Reviews in Biotechnology, 2020In the whole life process, many factors including external and internal factors affect plant growth and development. The morphogenesis, growth, and development of plants are controlled by genetic elements and are influenced by environmental stress ...
Kai Feng +8 more
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The quantitative genetics of transcription
Trends in Genetics, 2005Quantitative geneticists have become interested in the heritability of transcription and detection of expression quantitative trait loci (eQTLs). Linkage mapping methods have identified major-effect eQTLs for some transcripts and have shown that regulatory polymorphisms in cis and in trans affect expression.
Gibson, Greg, Weir, Bruce
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Visualization of Genetic Transcription
1973Transcription of structural genes by RNA polymerase to produce messenger RNAs (mRNAs) and the translation of such messengers by polyribosomes to produce proteins are intimately coupled processes in bacterial cells (1). In fact, it is possible to reconstruct coupled transcription and translation systems in vitro from separated bacterial components (2,3).
O. L. Miller, Barbara A. Hamkalo
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Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966
The purine and pyrimidine base sequence of DNA , permanent repository of the genetic information, must be transcribed on to ribopolynucleotides before genotype can be translated into phenotype. This transcription gives rise to three recognizably different classes of RNA molecules: (1) two ...
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The purine and pyrimidine base sequence of DNA , permanent repository of the genetic information, must be transcribed on to ribopolynucleotides before genotype can be translated into phenotype. This transcription gives rise to three recognizably different classes of RNA molecules: (1) two ...
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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.
New England Journal of Medicine, 1997In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to the site of lesions, thereby amplifying and perpetuating the ...
P. Barnes, M. Karin
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Transcriptional derepression as a cause of genetic diseases
Current Opinion in Genetics & Development, 2003Transcription of DNA into mRNA is a highly regulated process directed by a complex molecular machine comprising more than 100 proteins. Regulation of transcription occurs by both positive (transcriptional activation) and negative (transcriptional repression) mechanisms.
Michael R. Green +3 more
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