Results 261 to 270 of about 5,008,846 (367)

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Exploring the multifaceted dynamics of flowering time regulation in field crops: Insight and intervention approaches. [PDF]

Plant Genome
Naik YD, Bahuguna RN, Garcia-Caparros P, Zwart RS, Reddy MSS, Mir RR, Jha UC, Fakrudin B, Pandey MK, Challabathula D, Sharma VK, Reddy UK, Kumar CVS, Mendu V, Prasad PVV, Punnuri SM, Varshney RK, Thudi M.   +17 more
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Overexpression of the GmERF071 gene confers resistance to soybean cyst nematode in soybean. [PDF]

Plant Genome
Xiong E, Xu J, Feng P, Lian Y, Zhi X, Li K, Zhang E, Li B, Zhao S, Liu C, Wei C, Li P, Zhao Y, Zhao L, Zheng M, Zhang H, Li Y, Chu S, Jiao Y.   +18 more
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Tuning Ultrasensitivity in Genetic Logic Gates Using Antisense RNA Feedback. [PDF]

ACS Synth Biol
Engelmann N, Molderings M, Koeppl H.
europepmc   +1 more source

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism

Nature, 2015
D. Oldridge, A. Wood, Nina Weichert-Leahey, Ian Crimmins, Robyn T. Sussman, C. Winter, L. McDaniel, M. Diamond, Lori S. Hart, Shizhen Zhu, Adam D. Durbin, B. Abraham, L. Anders, Lifeng Tian, Shile Zhang, Jun S. Wei, J. Khan, K. Bramlett, N. Rahman, M. Capasso, A. Iolascon, D. Gerhard, J. G. Auvil, R. Young, H. Hakonarson, S. Diskin, A. Look, J. Maris   +27 more
semanticscholar   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Gene syntaxes modulate gene expression and circuit behavior on plasmids. [PDF]

J Biol Eng
Deng Y, Maurais HE, Etheridge K, Sarpeshkar R.   +3 more
europepmc   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source