Results 211 to 220 of about 2,206,258 (297)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Genome-wide Transcriptional Response during the Shift to N2-fixing Conditions in Heliobacterium modesticaldum

, 2018
Daniel E. Sheehy, Yih Kuang Lu, Fawsia Osman, Zana Alattar, Catalina Flores, Hallie Sussman, Sahba Zaare, Maria Dooling, Amir Meraban, Patricia L. Baker, Jeffrey W. Touchman, Kevin Redding   +11 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Structural insights into σ28-dependent transcription initiation and its regulation by anti-sigma factor in Pseudomonas aeruginosa. [PDF]

Nucleic Acids Res
Sheenu, Kumar V, Sahoo PK, Kandiah E, Jain D.   +4 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Molecular Mechanisms of the Phytohormone-Heat Shock Protein Pathway in Regulating Plant Thermotolerance. [PDF]

Plants (Basel)
Zhang J, Zhu Y, Ma F, Zou X, Lan Q, Zhou X, Li M, Zhou F, Yin C, Lin Y.   +9 more
europepmc   +1 more source

Trashing transcription [PDF]

Nature Chemical Biology, 2019
openaire   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis.

Endocr Rev
Chang M, Wang JC.
europepmc   +1 more source