Results 31 to 40 of about 3,486,426 (236)

Precision of readout at the hunchback gene: analyzing short transcription time traces in living fly embryos [PDF]

, 2016
The simultaneous expression of the hunchback gene in the numerous nuclei of the developing fly embryo gives us a unique opportunity to study how transcription is regulated in living organisms.
Coppey, Mathieu, Desponds, Jonathan, Dostatni, Nathalie, Ferraro, Teresa, Fradin, Cecile, Guillou, Aurelien, Lucas, Tanguy, Romero, Carmina Perez, Tran, Huy, Walczak, Aleksandra M.   +9 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Justifications of a 21st century wind ensemble transcription of Mozart\u27s Overture to The Magic Flute based upon late eighteenth century ideology

, 2009
I will create a transcription for wind ensemble of the Overture to The Magic Flute by WA Mozart. By completing this transcription, a standard orchestral work will be available in comparable quality and difficulty for wind ensemble.
Stewart, Teresa Corinne
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Temperature-sensitive protein–DNA dimerizers [PDF]

, 2005
Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an ...
Ansari, Aseem Z., Arndt, Hans-Dieter, Dervan, Peter B., Hauschild, Karl E., Metzler, Renee E., Moretti, Rocco, Raffaelle, Marni   +6 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin [PDF]

, 2014
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs).
Alex D. Herbert, Amani Ismail, Andreas Kakarougkas, Anna L. Chambers, Brownlee, Campbell, Cao, Chambers, Chou, Enriqueta Riballo, Fradet-Turcotte, Francia, Ginjala, Goodarzi, Jessica A. Downs, Julia Künzel, Khavari, Lin, Markus Löbrich, Mathas, Matsuoka, Mattiroli, Mosesso, Noon, Oum, Papamichos-Chronakis, Penny A. Jeggo, Rulten, Schaaf, Shain, Shanbhag, Shema-Yaacoby, Shibata, Stiff, Varela, Vissers, Wei   +36 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Structural visualization of key steps in human transcription initiation. [PDF]

, 2013
Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie, He, Yuan, NOGALES, Eva, Taatjes, Dylan   +3 more
core   +1 more source

An Experimental Framework to Examine the Influence of Promoter Architecture and Genomic Context on Gene Expression [PDF]

, 2020
Transcription is a fundamental process of gene expression. Information stored in DNA is transcribed into different types of mobile RNA, which play a role in various essential processes of the cell, e.g. translation.
Klein, Carlo Anton
core   +1 more source