Results 31 to 40 of about 1,900,870 (246)
Transcription and cancer [PDF]
British Journal of Cancer, 1991 The normal growth, development and function of an organism requires precise and co-ordinated control of gene expression. A major part of this control is exerted by regulating messenger RNA (mRNA) production and involves complex interactions between an array of transcriptionally active proteins and specific regulatory DNA sequences.
Cox, P, Goding, C
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Transcription Factors Modulate c-Fos Transcriptional Bursts
Cell Reports, 2014 Transcription is a stochastic process occurring mostly in episodic bursts. Although the local chromatin environment is known to influence the bursting behavior on long timescales, the impact of transcription factors (TFs)—especially in rapidly inducible ...
Adrien Senecal +7 more
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BMC Molecular and Cell Biology, 2020 Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar +4 more
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Transcription and post-transcriptional regulation of spermatogenesis [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2010 Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards
Anilkumar Bettegowda, Miles F. Wilkinson
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Cell Reports, 2019 Summary: Despite substantial progress in our understanding of the players involved and the regulatory mechanisms controlling the initiation and elongation steps of transcription, little is known about the recruitment of elongation factors at promoter ...
Dipika Yadav +4 more
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Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme
eLife, 2020 PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1.
Roman O Fedoryshchak +10 more
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Transcriptional ShortCUTs [PDF]
Molecular Cell, 2008 Recent work from Kuehner and Brow (2008) and Thiebaut et al. (2008) in Molecular Cell and Jenks et al. (2008) in Molecular and Cellular Biology reveals that regulated expression of central nucleotide synthesis pathway components directs start site-dependent RNA polymerase II termination.
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Nature CommunicationsParacrine IL-2 signalling drives the CD8 + T cell expansion and differentiation that allow protection against viral infections, but the underlying molecular events are incompletely understood.
Diane Maurice +5 more
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Scientific Reports, 2017 The PBAF chromatin-remodeling complexes are multi-protein machines, regulating expression of genes involved in proliferation and differentiation. PHF10 is a subunit of the PBAF essential for its association with chromatin. Mammalian PHF10 is expressed as
Victor V. Tatarskiy +5 more
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eLife, 2014 Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture.
Ignacio Izeddin +11 more
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