Results 31 to 40 of about 2,190,849 (297)

Structural basis of eukaryotic transcription termination by the Rat1 exonuclease complex

Nature Communications
The 5´–3´ exoribonuclease Rat1/Xrn2 is responsible for the termination of eukaryotic mRNA transcription by RNAPII. Rat1 forms a complex with its partner proteins, Rai1 and Rtt103, and acts as a “torpedo” to bind transcribing RNAPII and dissociate DNA/RNA
Tatsuo Yanagisawa, Yuko Murayama, Haruhiko Ehara, Mie Goto, Mari Aoki, Shun-ichi Sekine   +5 more
doaj   +1 more source

Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP

Scientific Reports, 2017
The PBAF chromatin-remodeling complexes are multi-protein machines, regulating expression of genes involved in proliferation and differentiation. PHF10 is a subunit of the PBAF essential for its association with chromatin. Mammalian PHF10 is expressed as
Victor V. Tatarskiy, Yuriy P. Simonov, Dmitrii S. Shcherbinin, Alexander V. Brechalov, Sofia G. Georgieva, Nataliya V. Soshnikova   +5 more
doaj   +1 more source

Marine Antimicrobial Peptides-Based Strategies for Tackling Bacterial Biofilm and Biofouling Challenges

Molecules, 2022
An assemblage nexus of microorganisms enclosed in a composite extracellular polymeric matrix is called as a biofilm. The main factor causing biological fouling, or biofouling, is biofilms. Biofilm-mediated biofouling is a significant detrimental issue in
Anupam Patra, Jhilik Das, Nupur Rani Agrawal, Gajraj Singh Kushwaha, Mrinmoy Ghosh, Young-Ok Son   +5 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

eLife, 2020
PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1.
Roman O Fedoryshchak, Magdalena Přechová, Abbey M Butler, Rebecca Lee, Nicola O'Reilly, Helen R Flynn, Ambrosius P Snijders, Noreen Eder, Sila Ultanir, Stephane Mouilleron, Richard Treisman   +10 more
doaj   +1 more source

Transcription mechanisms [PDF]

WormBook, 2006
Appropriate regulation of mRNA transcription is central to the differentiation and functions of eukaryotic cells, and to the development of complex organisms. mRNAs are synthesized by the coordinated action of a set of general transcription and mRNA modification factors.
T Keith, Blackwell, Amy K, Walker
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Role of FlhF and its domains in the assembly of a polar flagellum in P. aeruginosa

Journal of Bacteriology
FlhF, an SRP GTPase, regulates the polarity and flagellation patterns in various bacteria, including Pseudomonas aeruginosa. FlhF is a multidomain protein that comprises three domains: B, N, and G, or the GTPase domain.
Shikha Raghav, Rohit Prajapati, Deepti Jain   +2 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

eLife, 2014
Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture.
Ignacio Izeddin, Vincent Récamier, Lana Bosanac, Ibrahim I Cissé, Lydia Boudarene, Claire Dugast-Darzacq, Florence Proux, Olivier Bénichou, Raphaël Voituriez, Olivier Bensaude, Maxime Dahan, Xavier Darzacq   +11 more
doaj   +1 more source