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TF Profiler: a transcription factor inference method that broadly measures transcription factor activity and identifies mechanistically distinct networks [PDF]
Genome BiologyTF Profiler is a method of inferring transcription factor (TF) regulatory activity, i.e., when a TF is present and actively participating in the regulation of transcription, directly from nascent sequencing assays such as PRO-seq and GRO-seq.
Taylor Jones +5 more
doaj +2 more sources
Transcription factor condensates and signaling driven transcription
Nucleus, 2023 Transcription Factor (TF) condensates are a heterogenous mix of RNA, DNA, and multiple co-factor proteins capable of modulating the transcriptional response of the cell.
Rajat Mann, Dimple Notani
doaj +1 more source
Dynamics of transcription factor binding site evolution [PDF]
, 2015 Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key regulatory ...
Barton, Nicholas H. +3 more
core +13 more sources
The Role of the Transcription Factor EGR1 in Cancer
Frontiers in Oncology, 2021 Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis.
Bin Wang +5 more
semanticscholar +1 more source
The ets-related transcription factor GABP directs bidirectional transcription. [PDF]
PLoS Genetics, 2007 Approximately 10% of genes in the human genome are distributed such that their transcription start sites are located less than 1 kb apart on opposite strands. These divergent gene pairs have a single intergenic segment of DNA, which in some cases appears
Patrick J Collins +4 more
doaj +1 more source
KLF4 transcription factor in tumorigenesis
Cell Death Discovery, 2023 Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death.
Zhihong He, Jie He, Keping Xie
doaj +1 more source
NRF2, a Transcription Factor for Stress Response and Beyond
International Journal of Molecular Sciences, 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
Feng He, Xiaoli Ru, T. Wen
semanticscholar +1 more source
Optimization of Transcription Factor Genetic Circuits
Biology, 2022 Transcription factors (TFs) affect the production of mRNAs. In essence, the TFs form a large computational network that controls many aspects of cellular function. This article introduces a computational method to optimize TF networks. The method extends
Steven A. Frank
doaj +1 more source
mBio, 2020 Bacterial gene regulation is governed by often hundreds of transcription factors (TFs) that bind directly to targets on the chromosome. Global studies of TFs usually make assumptions that regulatory targets within model strains will be conserved between ...
James P. R. Connolly +2 more
doaj +1 more source
A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks [PDF]
, 2005 Background Transcription regulatory networks are composed of interactions between transcription factors and their target genes. Whereas unicellular networks have been studied extensively, metazoan transcription regulatory networks remain largely ...
Deplancke, B. +5 more
core +2 more sources