Results 11 to 20 of about 1,572,227 (290)
Eukaryotic transcription factors [PDF]
Biochemical Journal, 1990 AbstractMany nuclear proteins have been found recently to interact with short conserved sequences which are involved in regulating the transcription of various genes. Nuclear transcription factors may be arbitrarily subdivided into two groups, ubiquitous and tissue‐specific.
O L, Polyanovsky, A G, Stepchenko
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Transcription factor condensates and signaling driven transcription
Nucleus, 2023 Transcription Factor (TF) condensates are a heterogenous mix of RNA, DNA, and multiple co-factor proteins capable of modulating the transcriptional response of the cell.
Rajat Mann, Dimple Notani
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Transcription Factor Dynamics [PDF]
Cold Spring Harbor Perspectives in Biology, 2021 To predict transcription, one needs a mechanistic understanding of how the numerous required transcription factors (TFs) explore the nuclear space to find their target genes, assemble, cooperate, and compete with one another. Advances in fluorescence microscopy have made it possible to visualize real-time TF dynamics in living cells, leading to two ...
Feiyue Lu, Timothée Lionnet
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The ets-related transcription factor GABP directs bidirectional transcription. [PDF]
PLoS Genetics, 2007 Approximately 10% of genes in the human genome are distributed such that their transcription start sites are located less than 1 kb apart on opposite strands. These divergent gene pairs have a single intergenic segment of DNA, which in some cases appears
Patrick J Collins +4 more
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KLF4 transcription factor in tumorigenesis
Cell Death Discovery, 2023 Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death.
Zhihong He, Jie He, Keping Xie
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Smad transcription factors [PDF]
Genes & Development, 2005 Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
Joan, Massagué +2 more
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FOXO transcription factors [PDF]
Current Biology, 2007 What are they? FOXO proteins are a subgroup of the Forkhead family of transcription factors. This family is characterized by a conserved DNA-binding domain (the ‘Forkhead box’, or FOX) and comprises more than 100 members in humans, classified from FOXA to FOXR on the basis of sequence similarity.
Carter, Matthew E., Brunet, Anne
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PLoS Computational Biology, 2013 Despite explosive growth in genomic datasets, the methods for studying epigenomic mechanisms of gene regulation remain primitive. Here we present a model-based approach to systematically analyze the epigenomic functions in modulating transcription factor-
Chieh-Chun Chen +7 more
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Transforming a transcription factor
eLife, 2018 A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
Robert D Burke
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mBio, 2020 Bacterial gene regulation is governed by often hundreds of transcription factors (TFs) that bind directly to targets on the chromosome. Global studies of TFs usually make assumptions that regulatory targets within model strains will be conserved between ...
James P. R. Connolly +2 more
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