In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]
, 2015 Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana +9 more
core +3 more sources
3D polymer simulations of genome organization and transcription across different chromosomes and cell types [PDF]
, 2022 We employ the diffusing transcription factors model for numerical simulation of chromatin topology conformations and transcriptional processes of human chromatin. Simulations of a short chromatin filament reveal different possible pathways to regulate transcription: it is shown that the transcriptional activity profile can be regulated and controlled ...
arxiv +1 more source
Predicting Combinatorial Binding of Transcription Factors to Regulatory Elements in the Human Genome by Association Rule Mining [PDF]
, 2007 Cis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Although some cisregulatory elements have been well studied, the combinations of transcription
Iyer, Vishwanath R. +3 more
core +2 more sources
Adaptive evolution of transcription factor binding sites [PDF]
, 2004 The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in the ...
Berg, Johannes +2 more
core +4 more sources
The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells [PDF]
, 2007 Gefitinib is a specific inhibitor of the epidermal growth factor receptor (EGFR) that causes growth delay in cancer cell lines and human tumor xenografts expressing high levels of EGFR.
Albergaria, André +6 more
core +1 more source
Human transcription factor protein interaction networks
Nature Communications, 2022 Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here the authors identify 6703 and 1536 protein–protein interactions for 109 different human TFs through BioID and AP-MS analyses, respectively.
Helka Göös +8 more
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2020 Background In the human genome, the transcription factors (TFs) and transcription factor‐binding sites (TFBSs) network has a great regulatory function in the biological pathways.
Shirin Moradifard +4 more
doaj +1 more source
Protein Evolution in Yeast Transcription Factor Subnetworks [PDF]
, 2010 When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-
Franzosa, Eric A. +3 more
core +3 more sources
Re-utilization of a transcription factor
eLife, 2016 The temporal transcription factor Krüppel has a dual role in the development of neurons.
Filipe Pinto-Teixeira, Claude Desplan
doaj +1 more source
Using temporal correlation in factor analysis for reconstructing transcription factor activities [PDF]
, 2008 Two-level gene regulatory networks consist of the transcription factors (TFs) in the top level and their regulated genes in the second level. The expression profiles of the regulated genes are the observed high-throughput data given by experiments such ...
Pournara, Iosifina, Wernisch, Lorenz
core +5 more sources