Results 31 to 40 of about 15,541,955 (379)

A preliminary computational outputs versus experimental results: Application of sTRAP, a biophysical tool for the analysis of SNPs of transcription factor‐binding sites

Molecular Genetics & Genomic Medicine, 2020
Background In the human genome, the transcription factors (TFs) and transcription factor‐binding sites (TFBSs) network has a great regulatory function in the biological pathways.
Shirin Moradifard, Reza Saghiri, Parastoo Ehsani, Fatemeh Mirkhani, Mina Ebrahimi‐Rad   +4 more
doaj   +1 more source

Transcription Factor Binding to Replicated DNA

Cell Reports, 2020
Summary: Genome replication perturbs the DNA regulatory environment by displacing DNA-bound proteins, replacing nucleosomes, and introducing dosage imbalance between regions replicating at different S-phase stages.
Raz Bar-Ziv, Sagie Brodsky, Michal Chapal, Naama Barkai   +3 more
doaj   +1 more source

Transcription factor EB regulates cardiovascular homeostasis

EBioMedicine, 2021
Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator ...
Haocheng Lu, Jinjian Sun, Milton H. Hamblin, Y. Eugene Chen, Yanbo Fan   +4 more
doaj   +1 more source

Pleiotropic functions for transcription factor zscan10. [PDF]

PLoS ONE, 2014
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays.
Petra Kraus, Sivakamasundari V, Hong Bing Yu, Xing Xing, Siew Lan Lim, Thure Adler, Juan Antonio Aguilar Pimentel, Lore Becker, Alexander Bohla, Lillian Garrett, Wolfgang Hans, Sabine M Hölter, Eva Janas, Kristin Moreth, Cornelia Prehn, Oliver Puk, Birgit Rathkolb, Jan Rozman, Jerzy Adamski, Raffi Bekeredjian, Dirk H Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Frauke Neff, Markus Ollert, Tobias Stoeger, Ali Önder Yildrim, Oliver Eickelberg, Eckhard Wolf, Wolfgang Wurst, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Thomas Lufkin, Lawrence W Stanton   +35 more
doaj   +1 more source

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources

Transcription Factor KLF14 and Metabolic Syndrome

Frontiers in Cardiovascular Medicine, 2020
Metabolic syndrome (MetSyn) is a combination of metabolic abnormalities that lead to the development of cardiovascular disease (CVD) and Type 2 Diabetes (T2D).
Qianyi Yang, Mete Civelek, Mete Civelek
doaj   +1 more source

Predicting Transcription Factor Specificity with All-Atom Models [PDF]

, 2008
The binding of a transcription factor (TF) to a DNA operator site can initiate or repress the expression of a gene. Computational prediction of sites recognized by a TF has traditionally relied upon knowledge of several cognate sites, rather than an ab ...
Arvidson, Benos, Blattner, Djordjevic, Donald, Endres, Endres, Foat, Glasfeld, He, Humphrey, Ingraham, Kalodimos, Kazakov, Kinney, Kullback, Lafontaine, Leonid A. Mirny, Liu, Lu, MacKerell, Maerkl, Man, Mehran Kardar, Meng, Mironov, Morozov, Onufriev, Paillard, Paillard, Peter Virnau, Pérez, Sahand J. Rahi, Schumacher, von Hippel, Wang   +35 more
core   +3 more sources

Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor

International Journal of Endocrinology, 2011
The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal ...
Bynthia M. Anose, Michel M. Sanders
doaj   +1 more source

SUMOylation of zebrafish transcription factor Zbtb21 affects its transcription activity [PDF]

PeerJ
Background Post-translational modification by Small Ubiquitin-like MOdifier (SUMO) is an important mechanism to regulate protein activity, protein stability, and localization of substrates.
Zhou Fang, Yun Deng, Haihong Wang, Jun Zhou   +3 more
doaj   +2 more sources

Determinants of transcription factor regulatory range

Nature Communications, 2020
Characterization of the distance over which TF binding influences gene expression is important for inferring target genes. Here the authors study this relationship using thousands of genomic data sets, finding two classes of TFs with distinct ranges of ...
Chen-Hao Chen, Rongbin Zheng, Collin Tokheim, Xin Dong, Jingyu Fan, Changxin Wan, Qin Tang, Myles Brown, Jun S. Liu, Clifford A. Meyer, X. Shirley Liu   +10 more
doaj   +1 more source