Results 171 to 180 of about 5,388 (199)

Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse

Somatic Cell and Molecular Genetics, 1995
Heavy metal-induced transcription in mammalian cells is conferred by the metal-responsive 70 kDa transcription factor MTF-1 which contains six zinc fingers and at least three activation domains. In previous cell transfection experiments we have shown that the zinc finger region confers an about 3 fold metal inducibility of transcription, due to its ...
H P, Müller, E, Brungnera, O, Georgiev, M, Badzong, K H, Müller, W, Schaffner   +5 more
openaire   +2 more sources

Putting its fingers on stressful situations: the heavy metal‐regulatory transcription factor MTF‐1

BioEssays, 2001
AbstractIt has been suggested that metallothioneins, discovered about 45 years ago, play a central role in heavy metal metabolism and detoxification, and in the management of various forms of stress. The metal‐regulatory transcription factor‐1 (MTF‐1) was shown to be essential for basal and heavy metal‐induced transcription of the stress‐responsive ...
P, Lichtlen, W, Schaffner
openaire   +2 more sources

Zinc-sensitive genes as potential new target genes of the metal transcription factor-1 (MTF-1)

Biochemistry and Cell Biology, 2005
Zinc is an essential trace element that serves as a structural constituent of a large number of transcription factors, which explains its pivotal role in the control of gene expression. Previous studies investigating the effect of zinc deficiency and zinc supplementation on gene expression in the human adenocarcinoma cell line HT-29 led to the ...
Birgit, Kindermann, Frank, Döring, Jan, Budczies, Hannelore, Daniel   +3 more
openaire   +2 more sources

Identification of a splice variant of the metal-responsive transcription factor MTF-1 in common carp

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2009
Transactivation of the expression of metallothionein genes involves the Metal-responsive Transcription Factor (MTF-1). We report here the identification of mtf-1.1a, the first known splice variant of mtf-1.1 mRNA, in common carp (Cyprinus carpio).
Agnes, Ferencz, Edit, Hermesz
openaire   +2 more sources

Role of metal‐responsive transcription factor‐1 (MTF‐1) in EGF‐dependent DNA synthesis in primary hepatocytes

Journal of Cellular Biochemistry, 2006
AbstractMetal‐responsive transcription factor‐1 (MTF‐1), which is involved in sensing heavy metal load, induces the transcription of several protective genes. The mouse Mtf‐1 gene is essential, and Mtf‐1−/− embryos die from liver degeneration. We showed that DNA synthesis induced in hepatocytes by epidermal growth factor (EGF) was delayed by inhibition
Tomoki, Kimura, Norio, Itoh, Tomomichi, Sone, Masuo, Kondoh, Keiichi, Tanaka, Masakazu, Isobe   +5 more
openaire   +2 more sources

Molecular Cloning and Developmental Expression of Zinc Finger Transcription Factor MTF-1 Gene in Zebrafish, Danio rerio

Biochemical and Biophysical Research Communications, 2002
Metal-responsive transcription factor, MTF-1 is a zinc finger protein, shown to be essential for embryonic development. Homozygous knockout mouse embryos for MTF-1 die in utero at day 14 of gestation, due to liver decay. In the present study, we report the complete nucleotide sequence of cDNA encoding zebrafish MTF-1 and the amino acid sequence ...
Wen-Ya, Chen, Joseph Abraham Christopher, John, Chen-Hui, Lin, Chi-Yao, Chang   +3 more
openaire   +2 more sources

Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1α and MTF-1

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2004
Solid tumors are known to develop microenvironmental hypoxia or anoxia due to malfunction and malformation of blood vessels and the energy demands of the highly proliferative tumor cells. Oxygen deprivation can cause aberrant modifications of signaling pathways and their downstream transcription factors that are believed to contribute to malignancy ...
openaire   +2 more sources

Roles of zinc fingers and other regions of the transcription factor human MTF-1 in zinc-regulated DNA binding

Journal of Cellular Physiology, 2000
Mammalian metallothionein genes are transcriptionally regulated by heavy metals through cis-acting metal responsive elements (MREs). The MRE-binding transcription factor-1 (MTF-1), a protein containing six C(2)H(2)-type Zn fingers, is essential for MRE-mediated transcriptional activation.
S, Koizumi, K, Suzuki, Y, Ogra, P, Gong, F, Otuska   +4 more
openaire   +2 more sources

Nitric oxide-induced nuclear translocation of the metal responsive transcription factor, MTF-1 is mediated by zinc release from metallothionein

Vascular Pharmacology, 2006
We previously showed that the major Zn-binding protein, metallothionein (MT) is a critical target for nitric oxide (NO) with resultant increases in labile Zn. We now show that NO donors also affected the activity of the metal responsive transcription factor MTF-1 that translocates from the cytosol to the nucleus in response to physiologically relevant ...
Molly S, Stitt, K J, Wasserloos, X, Tang, X, Liu, Bruce R, Pitt, Claudette M, St Croix   +5 more
openaire   +2 more sources

The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
Metallothionein (MT) is a small, cysteine-rich protein active in zinc homeostasis, cadmium detoxification, and protection against reactive oxygen species. Mouse MT-I gene transcription is regulated by metal response element-binding transcription factor-1 (MTF-1), which is recruited to the promoter by zinc.
Fumika, Okumura, Yong, Li, Norio, Itoh, Tsuyoshi, Nakanishi, Masakazu, Isobe, Glen K, Andrews, Tomoki, Kimura   +6 more
openaire   +2 more sources