Results 41 to 50 of about 35,051 (207)

Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production.

PLoS ONE, 2010
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorder (HAND) is likely neuroinflammatory in origin, believed to be triggered by inflammatory and oxidative stress responses to cytokines and HIV protein gene products such as the HIV ...
Michelle Kiebala, Oksana Polesskaya, Zhenqiang Yao, Seth W Perry, Sanjay B Maggirwar   +4 more
doaj   +1 more source

The NF-κB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: The transcription factor NF-κB consisting of the subunits RelA/p65 and p50 is known to be quickly activated after partial hepatectomy (PH), the functional relevance of which is still a matter of debate.
Marc Ringelhan, Roland M Schmid, Fabian Geisler   +2 more
doaj   +1 more source

Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks. [PDF]

PLoS Genetics, 2011
The sirtuin Sirt6 is a NAD-dependent histone deacetylase that is implicated in gene regulation and lifespan control. Sirt6 can interact with the stress-responsive transcription factor NF-κB and regulate some NF-κB target genes, but the full scope of ...
Tiara L A Kawahara, Nicole A Rapicavoli, Angela R Wu, Kun Qu, Stephen R Quake, Howard Y Chang   +5 more
doaj   +1 more source

Activation of RelA homodimers by tumour necrosis factor α: a possible transcriptional activator in human vascular endothelial cells [PDF]

Biochemical Journal, 2005
In vascular endothelial cells, cytokines induce genes that are expressed in inflammatory lesions partly through the activation of transcription factor NF-κB (nuclear factor-κB). Among the members of the NF-κB/rel protein family, homodimers of the RelA subunit of NF-κB can also function as strong transactivators when expressed in cells.
Nobuyuki, Marui, Russell M, Medford, Mushtaq, Ahmad   +2 more
openaire   +2 more sources

Involvement of RelA-Associated Inhibitor in Regulation of Trophoblast Differentiation via Interaction with Transcriptional Factor Specificity Protein-1 [PDF]

Endocrinology, 2007
Glucose transporter-1 (GLUT1), one of the key functional indicators of placental differentiation, has an important role in placental glucose transport. We previously showed that the protein levels of GLUT1 and nuclear transcription factor specificity protein-1 (Sp1) in rat choriocarcinoma cells (Rcho-1 cells) decreased during the differentiation of ...
Ryoko, Minekawa, Masahiro, Sakata, Yoko, Okamoto, Masami, Hayashi, Aki, Isobe, Takashi, Takeda, Toshiya, Yamamoto, Masayasu, Koyama, Masahide, Ohmichi, Keiichi, Tasaka, Kenichi, Imai, Takashi, Okamoto, Yuji, Murata   +12 more
openaire   +2 more sources

Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.

PLoS ONE, 2022
Acyl-CoA synthetase 1 (ACSL1) is an enzyme that converts fatty acids to acyl-CoA-derivatives for lipid catabolism and lipid synthesis in general and can provide substrates for the production of mediators of inflammation in monocytes and macrophages ...
Prashanth Thevkar-Nagesh, Justine Habault, Maud Voisin, Sophie E Ruff, Susan Ha, Rachel Ruoff, Xi Chen, Shruti Rawal, Tarik Zahr, Gyongyi Szabo, Inez Rogatsky, Edward A Fisher, Michael J Garabedian   +12 more
doaj   +1 more source

Cyclic-AMP Increases Nuclear Actin Monomer Which Promotes Proteasomal Degradation of RelA/p65 Leading to Anti-Inflammatory Effects

Cells, 2022
The second messenger, cAMP has potent immunosuppressive and anti-inflammatory actions. These have been attributed, in part, to the ability of cAMP-induced signals to interfere with the function of the proinflammatory transcription factor Nuclear Factor ...
Joseph W. Hawkins, Madeleine C. McNeill, Reza Ebrahimighaei, Harry H. Mellor, Andrew C. Newby, Mark Bond   +5 more
doaj   +1 more source

RelA and RelB Transcription Factors in Distinct Thymocyte Populations Control Lymphotoxin-Dependent Interleukin-17 Production in γδ T Cells [PDF]

Immunity, 2011
The NF-κB transcription factor regulates numerous immune responses but its contribution to interleukin-17 (IL-17) production by T cells is largely unknown. Here, we report that IL-17, but not interferon-γ (IFN-γ), production by γδ T cells required the NF-κB family members RelA and RelB as well as the lymphotoxin-β-receptor (LTβR).
Powolny-Budnicka, Iwona, Riemann, Marc, Tänzer, Simone, Schmid, Roland M., Hehlgans, Thomas, Weih, Falk   +5 more
openaire   +2 more sources

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

Zfp521 is essential for the quiescence and maintenance of adult hematopoietic stem cells under stress

iScience, 2021
Summary: Zinc finger protein 521 (Zfp521), a quiescent hematopoietic stem cell (HSC)-enriched transcription factor, is involved in the self-renewal and differentiation of fetal liver HSC. However, its role in adult hematopoiesis remains elusive. Here, we
Zhigang Li, Xuemei Fu, Weiru Wu, Zhilong Liu, Zhe Chen, Chengfang Zhou, Yuanyuan Liu, Mei Kuang, Fangfang Sun, Feifei Xiao, Yongxiu Huang, Xiaojun Zhang, Shijun Fan, Xingqin Huang, Guangling Zheng, Jieping Chen, Yu Hou   +16 more
doaj   +1 more source