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The Human Transcription Factors [PDF]

Cell, 2018
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and transcription, forming a complex system that guides expression of the genome. Despite keen interest in understanding how TFs control gene expression, it remains challenging to determine how the precise genomic binding sites of TFs are specified and how TF binding ...
Samuel A. Lambert, A. Jolma, L. Campitelli, P. Das, Yimeng Yin, Mihai Albu, Xiaoting Chen, J. Taipale, T. Hughes, M. Weirauch   +9 more
semanticscholar   +7 more sources

Transcription factors in microcephaly

Frontiers in Neuroscience, 2023
Higher cognition in humans, compared to other primates, is often attributed to an increased brain size, especially forebrain cortical surface area. Brain size is determined through highly orchestrated developmental processes, including neural stem cell ...
Youngshin Lim, Youngshin Lim
doaj   +3 more sources

Transcription Factors in Biocontrol Fungi [PDF]

Journal of Fungi
Transcription factors are extensively found in fungi and are involved in the regulation of multiple biological processes, including growth, development, conidiation, morphology, stresses tolerance, and virulence, as well as the production of secondary ...
Han-Jian Song, Xiao-Feng Li, Xin-Ran Pei, Zhan-Bin Sun, Han-Xu Pan   +4 more
doaj   +2 more sources

Smad transcription factors. [PDF]

Genes & Development, 2005
Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology-the transforming growth factor-beta (TGFbeta) pathway.
J. Massagué, J. Seoane, D. Wotton
semanticscholar   +3 more sources

Targeting Transcription Factors for Cancer Treatment

Molecules, 2018
Transcription factors are involved in a large number of human diseases such as cancers for which they account for about 20% of all oncogenes identified so far. For long time, with the exception of ligand-inducible nuclear receptors, transcription factors
Mélanie Lambert, Samy Jambon, Sabine Depauw, Marie-Hélène David-Cordonnier   +3 more
doaj   +2 more sources

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Cell, 2018
Ann Boija, Isaac A Klein, Benjamin R Sabari   +2 more
exaly   +2 more sources

Targeting transcription factors in cancer — from undruggable to reality

Nature Reviews Cancer, 2019
John H Bushweller
exaly   +2 more sources

Triple-negative and triple-positive breast cancer cells reciprocally control their growth and migration via the S100A4 pathway

Cell Adhesion & Migration, 2022
The study’s aim was to investigate the S100A4-mediated mechanisms of the regulation of tumor cell proliferation and migration in the human triple-positive breast carcinoma cell line MCF-7 (TPBC) and triple-negative breast carcinoma cell line MDA-MB-231 ...
Elena A. Dukhanina, Tatiana N. Portseva, Alexander S. Dukhanin, Sofia G. Georgieva   +3 more
doaj   +1 more source

Multiple Functions of MYB Transcription Factors in Abiotic Stress Responses

International Journal of Molecular Sciences, 2021
Plants face a more volatile environment than other organisms because of their immobility, and they have developed highly efficient mechanisms to adapt to stress conditions.
Xiaopei Wang, Ya Niu, Yuan Zheng
semanticscholar   +1 more source

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Frontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova, Nataliya V. Soshnikova, Nataliya V. Soshnikova, Asya M. Azieva, Asya M. Azieva, Nataliya S. Klimenko, Alvina I. Khamidullina, Alexey V. Feoktistov, Alexey V. Feoktistov, Andrey A. Sheynov, Alexander V. Brechalov, Victor V. Tatarskiy, Sofia G. Georgieva   +12 more
doaj   +1 more source