Results 61 to 70 of about 15,584,477 (336)

Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos. [PDF]

, 2018
The regulation of transcription requires the coordination of numerous activities on DNA, yet how transcription factors mediate these activities remains poorly understood.
Darzacq, Xavier, Eisen, Michael B, Hannon, Colleen E, Harrison, Melissa M, Mir, Mustafa, Ortiz, Stephan A, Stadler, Michael R   +6 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Transcription factors - Methods and protocols

European Journal of Histochemistry, 2011
A hearty wellcome to prof. Higgins editorial toil: a necessary tool for those colleagues (young and older) fighting each day with the transcription factor they are involved with.
CarloAlberto Redi
doaj   +1 more source

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

An RxLR effector from phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus [PDF]

, 2013
The plant immune system is activated following the perception of exposed, essential and invariant microbial molecules that are recognised as non-self. A major component of plant immunity is the transcriptional induction of genes involved in a wide array ...
A Block, A Bombarely, A Stamatakis, AN Olsen, AO Avrova, AP Rehmany, BJ Haas, BM Tyler, Brett Tyler, C Lacomme, C Zipfel, D Chinchilla, D Darriba, D Dou, DGO Saunders, EA van der Biezen, EM Gilroy, EM Gilroy, G Fabro, H-K Yoon, Hazel McLellan, HM Nguyen, HP Nguyen, I Hein, JD Jones, JIB Bos, Jim L. Beynon, JL Dangl, Juan Morales, K Bouwmeester, L Baxter, L Deslandes, Leighton Pritchard, M Karimi, M-C Caillaud, MD Curtis, Miles R. Armstrong, MS Mukhtar, N Ishihama, NK Clay, P Chomczynski, Paul R. J. Birch, Petra C. Boevink, PJ Seo, PJ Seo, PRJ Birch, PRJ Birch, Q Wang, S Capella-Gutierrez, S Dong, S Lee, S Moller, S Puranik, S Rivas, S-G Kim, S-Y Kim, SC Whisson, SK Oh, Sonia Gomez, SR Eddy, Stephen C. Whisson, T Boller, T Hoppe, T Ren, T Ren, TO Bozkurt, V Senchou, Y Liu, Y-J Lu, Y-S Kim, Z Nimchuk   +70 more
core   +4 more sources

Research advances of MYB transcription factors in plant stress resistance and breeding

Plant Signalling & Behavior, 2019
Plants face various stresses during the growth and development processes. The specific transcription factors bind to the cis-acting elements upstream of the stress resistance genes, specifically regulating the expression of the gene in plants and ...
Jinlu Li, Guoliang Han, Cuifeng Sun, N. Sui   +3 more
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Prunus transcription factors: Breeding perspectives

Frontiers in Plant Science, 2015
Many plant processes depend on differential gene expression, which is generally controlled by complex proteins called transcription factors (TFs). In peach, 1,533 TFs have been identified, accounting for about 5.5% of the 27,852 protein-coding genes ...
Valmor João Bianchi, Manuel eRubio, Livio eTrainotti, Ignazio eVerde, Claudio eBonghi, Pedro eMartinez-Gomez   +5 more
doaj   +1 more source

The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression. [PDF]

, 2016
Basal-like breast cancers (BLBCs) are aggressive breast cancers associated with poor survival. Defining the key drivers of BLBC growth will allow identification of molecules for targeted therapy.
Brown, Powel H, Hilsenbeck, Susan G, Mazumdar, Abhijit, Savage, Michelle, Shepherd, Jonathan H, Tsimelzon, Anna, Uray, Ivan P   +6 more
core   +1 more source